In the modern day practice, there are two basic surgical principles applied in periodontology. One approach involves the removal of periodontally affected pockets by resection while the other approach considers the possibility of closing the periodontal pocket with surgical techniques aimed at regenerating the lost periodontal tissues. Placement of physical barriers prevents the ingrowth of epithelial and connective tissues in the defect and the formation of a long junctional epithelium that creates a favorable environment for the creation of new bone tissue and periodontal ligament (the so-called new attachment). Regeneration is described as the formation or re-establishment of lost or damaged tissue so that the structure and function of lost or damaged tissue is fully restored. The purpose of regenerative periodontal therapy is to restore the structure and function of the periodontium. The central principle of regenerative therapy is the repair and regeneration of the root cementum, periodontal ligament, and alveolar bone. There are several methods and materials available, namely the method of bone regeneration by open or closed root scaling and planing without the use of additional means (Open Flap Debridement ˗ OFD), a method that uses bone grafts or the replacements which is referred to as guided bone regeneration Guided Bone Regeneration (GBR), and finally Guided Tissue Regeneration (GTR). Tissues can also be stimulated to regenerate by the use of bioactive substances such as growth and differentiation factors or enamel matrix proteins. These methods and materials can be used alone or in combination. The most commonly used materials in clinical practice are bone grafts, occlusive membranes, and bioactive agents. K