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BPC 157 Therapy Heals Tendon Muscle Junction in Rats
The FASEB Journal - Experimental Biology Meeting, EB 2018, 32 (2018), S1; 832.13. https://doi.org/10.1096/fasebj.2018.32.1_supplement.832.13
Japjec, Mladen; Staresinic, Mario; Sebecic, Bozidar; Pavlov, Katarina Horvat; Drmic, Domagoj; Vidovic, Tinka; Vlainic, Josipa; Seiwerth, Sven; Sikiric, Predrag

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Japjec, M., Staresinic, M., Sebecic, B., Pavlov, K. H., Drmic, D., Vidovic, T. ... Sikiric, P. (2018). BPC 157 Therapy Heals Tendon Muscle Junction in Rats. The FASEB Journal - Experimental Biology Meeting, EB 2018, 32. (S1), 832.13. doi: 10.1096/fasebj.2018.32.1_supplement.832.13

Japjec, Mladen, et al. "BPC 157 Therapy Heals Tendon Muscle Junction in Rats." The FASEB Journal - Experimental Biology Meeting, EB 2018, vol. 32, br. S1, 2018, str. 832.13. https://doi.org/10.1096/fasebj.2018.32.1_supplement.832.13

Japjec, Mladen, Mario Staresinic, Bozidar Sebecic, Katarina Horvat Pavlov, Domagoj Drmic, Tinka Vidovic, Josipa Vlainic, Sven Seiwerth i Predrag Sikiric. "BPC 157 Therapy Heals Tendon Muscle Junction in Rats." The FASEB Journal - Experimental Biology Meeting, EB 2018 32, br. S1 (2018): 832.13. https://doi.org/10.1096/fasebj.2018.32.1_supplement.832.13

Japjec, M., et al. (2018) 'BPC 157 Therapy Heals Tendon Muscle Junction in Rats', The FASEB Journal - Experimental Biology Meeting, EB 2018, 32(S1), str. 832.13. doi: 10.1096/fasebj.2018.32.1_supplement.832.13

Japjec M, Staresinic M, Sebecic B, Pavlov KH, Drmic D, Vidovic T, i sur.. BPC 157 Therapy Heals Tendon Muscle Junction in Rats. The FASEB Journal - Experimental Biology Meeting, EB 2018 [Internet]. 04.2018. [pristupljeno 02.04.2025.];32(S1):832.13. doi: 10.1096/fasebj.2018.32.1_supplement.832.13

M. Japjec, et al., "BPC 157 Therapy Heals Tendon Muscle Junction in Rats", The FASEB Journal - Experimental Biology Meeting, EB 2018, vol. 32, br. S1, str. 832.13, Travanj 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:264:248249. [Citirano: 02.04.2025.]

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Naslov (engleski)BPC 157 Therapy Heals Tendon Muscle Junction in Rats
AutorMladen Japjec
AutorMario Staresinic
AutorBozidar Sebecic
AutorKatarina Horvat Pavlov
AutorDomagoj Drmic
AutorTinka Vidovic
AutorJosipa Vlainic
AutorSven Seiwerth
AutorPredrag Sikiric
Autorova ustanova(Klinička bolnica Merkur)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Aim After tendon was separated from muscle in the right quadriceps muscle in rats, we focused on the tendon-muscle junction healing and therapy with the stable gastric pentadecapeptide BPC 157. Noteworthy, BPC 157 is an original antiulcer peptide, stable in human gastric juice, used in ulcerative colitis and now multiple sclerosis trials), with particular wound healing ability: healing of transected or crushed muscle, transected or detached tendon, and transected ligament, demonstrated... Više macro/microscopically, biomechanically and functionally (i.e., absent leg contracture), with parenteral and peroral therapy application (Curr Pharm Des. 2017 ; 23(27):4012– 4028 ; J Orthop Res. 2006 May ; 24(5):1109–17 ; J Orthop Res. 2006 May ; 24(5):982–9 ; J Orthop Res. 2003 Nov ; 21(6):976–83). Methods Under deep rat anesthesia tendon muscle junction of right quadriceps muscle was presented, and without direct transection of tendon muscle junction, the tendon was gently separated from muscle fibres. Medication was BPC 157 (10 ug or 10 ng/kg/day, intraperitoneally or in drinking water (0.16ug or 0.16ng/ml ; 12ml/rat/day) while controls received an equivolume of saline (5 ml/kg intraperitoneally) or drinking water only. Macro/microscopical, biomechanical assessment was at 1st, 2nd, 4th, and 6th week after surgery, while functional presentation (walking patterns, leg contracture) was daily assessed. Results Gross assessment reveals in quadriceps muscle a huge defect between tendon and muscle sustainably progressing throughout the experiment and failed healing. By contrast, in rats underwent tendon muscle junction separation that received BPC 157, the healing was continuously presented. Since very beginning, BPC 157 rats presented defect markedly less and finally grossly reestablished tendon muscle junction (Fig. 1). Also, controls exhibited severe leg contracture, and tottering walk, which were fully counteracted by BPC 157 therapy. These results are completely confirmed by microscopy. Illustratively, at 2nd week controls showed edema of the tendon with moderate lymphocytic infiltrate and formation of granulation tissue, while BPC 157 rats exhibited only minimal lymphocytic infiltrate with no granulation tissue formation in all pentadecapeptide BPC 157 treated animals and with better already reestablished myotendinous junction structures (Fig. 2). Likewise, biomechanic assessment demonstrated only a poor recovery of muscle strength in controls, while a full recovery ensues in BPC 157 treated rats. Conclusion In addition to the therapy of the injured muscle and tendon, BPC 157 therapy could also specifically benefit the injuries of tendon muscle junction. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Rad s konferencije
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaThe FASEB Journal - Experimental Biology Meeting, EB 2018
Brojčani podacivol. 32, br. S1, str. 832.13
p-ISSN0892-6638
e-ISSN1530-6860
DOIhttps://doi.org/10.1096/fasebj.2018.32.1_supplement.832.13
URN:NBNurn:nbn:hr:264:248249
Datum objave publikacije2018-04
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1096/fasebj.2018.32.1_supplement.832.13
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Javna napomenaThis abstract is from the Experimental Biology 2018 Meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. There is no full text article associated with this abstract published in The FASEB Journal.
Datum i vrijeme pohrane2022-12-23 10:30:22
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