prikaz prve stranice dokumenta Effect of Tff3 Deficiency and ER Stress in the Liver
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Effect of Tff3 Deficiency and ER Stress in the Liver
International Journal of Molecular Sciences, 20 (2019), 18; 1-19. https://doi.org/10.3390/ijms20184389
Šešelja, Kate; Bazina, Iva; Welss, Jessica; Schicht, Martin; Paulsen, Friedrich; Bijelić, Nikola; Rođak, Edi; Horvatić, Anita; Gelemanović, Andrea; Mihalj, Martina; Baus Lončar, Mirela

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Šešelja, K., Bazina, I., Welss, J., Schicht, M., Paulsen, F., Bijelić, N. ... Baus Lončar, M. (2019). Effect of Tff3 Deficiency and ER Stress in the Liver. International Journal of Molecular Sciences, 20. (18), 1-19. doi: 10.3390/ijms20184389

Šešelja, Kate, et al. "Effect of Tff3 Deficiency and ER Stress in the Liver." International Journal of Molecular Sciences, vol. 20, br. 18, 2019, str. 1-19. https://doi.org/10.3390/ijms20184389

Šešelja, Kate, Iva Bazina, Jessica Welss, Martin Schicht, Friedrich Paulsen, Nikola Bijelić, Edi Rođak, et al. "Effect of Tff3 Deficiency and ER Stress in the Liver." International Journal of Molecular Sciences 20, br. 18 (2019): 1-19. https://doi.org/10.3390/ijms20184389

Šešelja, K., et al. (2019) 'Effect of Tff3 Deficiency and ER Stress in the Liver', International Journal of Molecular Sciences, 20(18), str. 1-19. doi: 10.3390/ijms20184389

Šešelja K, Bazina I, Welss J, Schicht M, Paulsen F, Bijelić N, i sur.. Effect of Tff3 Deficiency and ER Stress in the Liver. International Journal of Molecular Sciences [Internet]. 2019. [pristupljeno 01.04.2025.];20(18):1-19. doi: 10.3390/ijms20184389

K. Šešelja, et al., "Effect of Tff3 Deficiency and ER Stress in the Liver", International Journal of Molecular Sciences, vol. 20, br. 18, str. 1-19, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:440497. [Citirano: 01.04.2025.]

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Podaci o radu
Naslov (engleski)Effect of Tff3 Deficiency and ER Stress in the Liver
AutorKate Šešelja
MBZ: 368290
AutorIva Bazina
AutorJessica Welss
AutorMartin Schicht
AutorFriedrich Paulsen
AutorNikola Bijelić
MBZ: 313935
AutorEdi Rođak
MBZ: 369662
AutorAnita Horvatić
MBZ: 316795
AutorAndrea Gelemanović
AutorMartina Mihalj
MBZ: 322792
AutorMirela Baus Lončar
MBZ: 222563
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
(Katedra za fiziologiju i imunologiju)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Klinička citologija
Sažetak (engleski)
Endoplasmic reticulum (ER) stress, a cellular condition caused by the accumulation of unfolded proteins inside the ER, has been recognized as a major pathological mechanism in a variety of conditions, including cancer, metabolic and neurodegenerative diseases. Trefoil factor family (TFFs) peptides are present in different epithelial organs, blood supply, neural tissues, as well as in the liver, and their deficiency has been linked to the ER function. Complete ablation of Tff3 expression is... Više observed in steatosis, and as the most prominent change in the early phase of diabetes in multigenic mouse models of diabesity. To elucidate the role of Tff3 deficiency on different pathologically relevant pathways, we have developed a new congenic mouse model Tff3-/-/C57BL6/N from a mixed background strain (C57BL6/N /SV129) by using a speed congenics approach. Acute ER stress was evoked by tunicamycin treatment, and mice were sacrificed after 24 h. Afterwards the effect of Tff3 deficiency was evaluated with regard to the expression of relevant oxidative and ER stress genes, relevant proinflammatory cytokines/chemokines, and the global protein content. The most dramatic change was noticed at the level of inflammation-related genes, while markers for unfolded protein response were not significantly affected. Ultrastructural analysis confirmed that the size of lipid vacuoles was affected as well. Since the liver acts as an important metabolic and immunological organ, the influence of Tff3 deficiency and physiological function possibly reflects on the whole organism. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 20, br. 18, str. 1-19
p-ISSN1661-6596
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms20184389
URN:NBNurn:nbn:hr:239:440497
Datum objave publikacije2019
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770867/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-01-17 13:00:59
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