prikaz prve stranice dokumenta Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack
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Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack
Immunity, 42 (2015), 2; 344-355. https://doi.org/10.1016/j.immuni.2015.01.010
Gur, Chamutal; Ibrahim, Yara; Isaacson, Batya; Yamin, Rachel; Abed, Jawad; Gamliel, Moriya; Enk, Jonatan; Bar-On, Yotam; Stanietsky-Kaynan, Noah; Coppenhagen-Glazer, Shunit; Shussman, Noam; Almogy, Gideon; Cuapio, Angelica; Hofer, Erhard; Mevorach, Dror; Tabib, Adi; Ortenberg, Rona; Markel, Gal; Miklić, Karmela; Jonjić, Stipan; Brennan, Caitlin A.; Garrett, Wendy S.; Bachrach, Gilad; Mandelboim, Ofer Više autora...

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Gur, C., Ibrahim, Y., Isaacson, B., Yamin, R., Abed, J., Gamliel, M. ... Mandelboim, O. (2015). Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack. Immunity, 42. (2), 344-355. doi: 10.1016/j.immuni.2015.01.010

Gur, Chamutal, et al. "Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack." Immunity, vol. 42, br. 2, 2015, str. 344-355. https://doi.org/10.1016/j.immuni.2015.01.010

Gur, Chamutal, Yara Ibrahim, Batya Isaacson, Rachel Yamin, Jawad Abed, Moriya Gamliel, Jonatan Enk, et al. "Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack." Immunity 42, br. 2 (2015): 344-355. https://doi.org/10.1016/j.immuni.2015.01.010

Gur, C., et al. (2015) 'Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack', Immunity, 42(2), str. 344-355. doi: 10.1016/j.immuni.2015.01.010

Gur C, Ibrahim Y, Isaacson B, Yamin R, Abed J, Gamliel M, i sur.. Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack. Immunity [Internet]. 02.2015. [pristupljeno 16.04.2024.];42(2):344-355. doi: 10.1016/j.immuni.2015.01.010

C. Gur, et al., "Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack", Immunity, vol. 42, br. 2, str. 344-355, Veljača 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:992646. [Citirano: 16.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:992646
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Naslov (engleski)Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack
AutorChamutal Gur
AutorYara Ibrahim
AutorBatya Isaacson
AutorRachel Yamin
AutorJawad Abed
AutorMoriya Gamliel
AutorJonatan Enk
AutorYotam Bar-On
AutorNoah Stanietsky-Kaynan
AutorShunit Coppenhagen-Glazer
AutorNoam Shussman
AutorGideon Almogy
AutorAngelica Cuapio
AutorErhard Hofer
AutorDror Mevorach
AutorAdi Tabib
AutorRona Ortenberg
AutorGal Markel
AutorKarmela Miklić
AutorStipan Jonjić
AutorCaitlin A. Brennan
AutorWendy S. Garrett
AutorGilad Bachrach
AutorOfer Mandelboim
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Bacteria, such as Fusobacterium nucleatum, are present in the tumor microenvironment. However, the immunological consequences of intra-tumoral bacteria remain unclear. Here, we have shown that natural killer (NK) cell killing of various tumors is inhibited in the presence of various F. nucleatum strains. Our data support that this F. nucleatum- mediated inhibition is mediated by human, but not by mouse TIGIT, an inhibitory receptor present on all human NK cells and on various T cells. Using a library of F. nucleatum mutants, we found that the Fap2 protein of F. nucleatum directly interacted with TIGIT, leading to the inhibition of NK cell cytotoxicity. We have further demonstrated that tumor- infiltrating lymphocytes expressed TIGIT and that T cell activities were also inhibited by F. nucleatum via Fap2. Our results identify a bacterium- dependent, tumorimmune evasion mechanism in which tumors exploit the Fap2 protein of F. nucleatum to inhibit immune cell activity via TIGIT.
Ključne riječi (hrvatski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaImmunity
Brojčani podacivol. 42, br. 2, str. 344-355
p-ISSN1074-7613
DOIhttps://doi.org/10.1016/j.immuni.2015.01.010
URN:NBNurn:nbn:hr:184:992646
Datum objave publikacije2015-02
ProjektŠifra: 322693
Naziv (engleski): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Kratica: STADVINN
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: 317013
Naziv (engleski): Natural Killer Cell-Based Anti-Cancer Immunotherapies:Research training in molecular medicine and biotechnology business
Kratica: NATURIMMUN
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: 320473
Naziv (engleski): Recognition of bacteria by NK cells
Kratica: BACNK
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S1074761315000369
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2018-12-04 22:13:52