prikaz prve stranice dokumenta IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma
  Preuzmi
PDF 1.81 MB
Znanstveni rad - Izvorni znanstveni rad
IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma
Cancers, 13 (2021), 17; 4306. https://doi.org/10.3390/cancers13174306
Maržić, Diana; Marijić, Blažen; Braut, Tamara; Janik, Stefan; Avirović, Manuela; Hadžisejdić, Ita; Tudor, Filip; Radobuljac, Katarina; Čoklo, Miran; Erovic, Boban M.

Citirajte ovaj rad

Maržić, D., Marijić, B., Braut, T., Janik, S., Avirović, M., Hadžisejdić, I. ... Erovic, B. M. (2021). IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma. Cancers, 13. (17). doi: 10.3390/cancers13174306

Maržić, Diana, et al. "IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma." Cancers, vol. 13, br. 17, 2021. https://doi.org/10.3390/cancers13174306

Maržić, Diana, Blažen Marijić, Tamara Braut, Stefan Janik, Manuela Avirović, Ita Hadžisejdić, Filip Tudor, Katarina Radobuljac, Miran Čoklo i Boban M. Erovic. "IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma." Cancers 13, br. 17 (2021). https://doi.org/10.3390/cancers13174306

Maržić, D., et al. (2021) 'IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma', Cancers, 13(17). doi: 10.3390/cancers13174306

Maržić D, Marijić B, Braut T, Janik S, Avirović M, Hadžisejdić I, i sur.. IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma. Cancers [Internet]. 26.08.2021. [pristupljeno 15.04.2024.];13(17). doi: 10.3390/cancers13174306

D. Maržić, et al., "IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma", Cancers, vol. 13, br. 17, Kolovoz 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:958258. [Citirano: 15.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:958258
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma
AutorDiana Maržić
AutorBlažen Marijić
AutorTamara Braut
AutorStefan Janik
AutorManuela Avirović
AutorIta Hadžisejdić
AutorFilip Tudor https://orcid.org/0000-0001-6386-0444
AutorKatarina Radobuljac
AutorMiran Čoklo
AutorBoban M. Erovic
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za otorinolaringologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Otorinolaringologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Background: The aim of this study was to (i) determine IMP3 protein expression in benign and malignant laryngeal lesions, (ii) compare its expression to Ki-67, p53, cyclin D1, and (iii) finally, to examine the prognostic power of IMP3 in squamous cell carcinomas of the larynx (LSSC). Methods: IMP3 protein expression was evaluated in 145 patients, including 62 LSCC, 45 dysplasia (25 with low and 20 with high-grade dysplasia), and 38 benign lesions (vocal cord polyps and nodules). Results: IMP3 was significantly higher expressed in LSCC compared to dysplasia and benign lesions (p < 0.001; p < 0.001, respectively). Similarly, higher expression patterns were observed for Ki-67 and p53, whereas cyclin D1 was equally distributed in all three lesions. IMP3 (p = 0.04) and Ki-67 (p = 0.02) expressions were significantly linked to neck node positivity, and IMP3 overexpression to worse disease-specific survival (p = 0.027). Conclusion: Since IMP3 showed significantly higher expression in laryngeal carcinomas, but not in high- or low-grade dysplasia, it serves as a useful marker to differentiate between invasive and noninvasive lesions. Higher IMP3 expression represented a significantly worse prognosticator for clinical outcomes of patients with squamous cell carcinoma of the larynx.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCancers
Brojčani podacivol. 13, br. 17, 4306
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers13174306
URN:NBNurn:nbn:hr:184:958258
Datum objave publikacije2021-08-26
ProjektŠifra: uniri-biomed-18-121
Naziv (hrvatski): Molekularni biomarkeri kancerogeneze u skvamoznim epitelnim lezijama grkljana
Naziv (engleski): Molecular biomarkers of cancerogenesis in laryngeal squamous epithelial lesions
Voditelj: Tamara Braut
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
ProjektŠifra: uniri-biomed-18-242
Naziv (hrvatski): Klinički značaj niske razine JAK2 V617F mutacije u perifernoj krvi: utjecaj na fenotip i prognozu
Naziv (engleski): Clinical significance of low level JAK2 V617F mutation in peripheral blood: effect on phenotype and prognosis
Voditelj: Ita Hadžisejdić
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttps://www.mdpi.com/2072-6694/13/17/4306
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Bez prerada 4.0 međunarodna (CC BY-ND 4.0)
Datum i vrijeme pohrane2021-10-26 12:13:04