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Nonalcoholic Fatty Liver Disease (NAFLD)—A New Cardiovascular Risk Factor in Peritoneal Dialysis Patients
Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 36 (2016), 4; 427-432. https://doi.org/10.3747/pdi.2014.00223
Mikolašević, Ivana; Milić, Sandra; Rački, Sanjin; Zaputović, Luka; Štimac, Davor; Radić, Mladen; Markić, Dean; Orlić, Lidija

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Mikolašević, I., Milić, S., Rački, S., Zaputović, L., Štimac, D., Radić, M. ... Orlić, L. (2016). Nonalcoholic Fatty Liver Disease (NAFLD)—A New Cardiovascular Risk Factor in Peritoneal Dialysis Patients. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 36. (4), 427-432. doi: 10.3747/pdi.2014.00223

Mikolašević, Ivana, et al. "Nonalcoholic Fatty Liver Disease (NAFLD)—A New Cardiovascular Risk Factor in Peritoneal Dialysis Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, vol. 36, br. 4, 2016, str. 427-432. https://doi.org/10.3747/pdi.2014.00223

Mikolašević, Ivana, Sandra Milić, Sanjin Rački, Luka Zaputović, Davor Štimac, Mladen Radić, Dean Markić i Lidija Orlić. "Nonalcoholic Fatty Liver Disease (NAFLD)—A New Cardiovascular Risk Factor in Peritoneal Dialysis Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 36, br. 4 (2016): 427-432. https://doi.org/10.3747/pdi.2014.00223

Mikolašević, I., et al. (2016) 'Nonalcoholic Fatty Liver Disease (NAFLD)—A New Cardiovascular Risk Factor in Peritoneal Dialysis Patients', Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 36(4), str. 427-432. doi: 10.3747/pdi.2014.00223

Mikolašević I, Milić S, Rački S, Zaputović L, Štimac D, Radić M, i sur.. Nonalcoholic Fatty Liver Disease (NAFLD)—A New Cardiovascular Risk Factor in Peritoneal Dialysis Patients. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis [Internet]. 01.07.2016. [pristupljeno 13.04.2025.];36(4):427-432. doi: 10.3747/pdi.2014.00223

I. Mikolašević, et al., "Nonalcoholic Fatty Liver Disease (NAFLD)—A New Cardiovascular Risk Factor in Peritoneal Dialysis Patients", Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, vol. 36, br. 4, str. 427-432, Srpanj 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:938792. [Citirano: 13.04.2025.]

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Naslov (engleski)Nonalcoholic Fatty Liver Disease (NAFLD)—A New Cardiovascular Risk Factor in Peritoneal Dialysis Patients
AutorIvana Mikolašević
AutorSandra Milić
AutorSanjin Rački
AutorLuka Zaputović
AutorDavor Štimac
AutorMladen Radić
AutorDean Markić
AutorLidija Orlić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background: Recent investigations indicated that nonalcoholic fatty liver disease (NAFLD), a hepatic component of metabolic syndrome (MS), is associated with an increased risk of cardiovascular disease (CVD). Accordingly, we were interested in exploring the frequency of NAFLD in peritoneal dialysis (PD) patients and analyzing factors in PD patients associated with NAFLD occurrence. In addition, we were interested in investigating whether NAFLD is associated with higher CVD risk in our PD... Više patients. ♦ Methods: In the present cross-sectional study, we analyzed 58 PD patients. The controlled attenuation parameter (CAP) was used to detect and quantify liver steatosis with the help of transient elastography (TE) (FibroScan, Echosense SA, Paris, France). A carotid ultrasound was performed in all patients to measure carotid intimae media thickness (IMT) and plaque as surrogate measures of increased CVD risk, and we investigated their association with NAFLD. ♦ Results: Nonalcoholic fatty liver disease was present in 74.1% of PD patients. Peritoneal dialysis/nonalcoholic fatty liver disease patients had statistically greater daily (136.5 ± 62.6 vs 93.6 ± 36.1; p = 0.02) and monthly (4,095.3 ± 1,877.7 vs 2,806.6 ± 1,083.2; p = 0.02) glucose load in comparison to the non-NAFLD/PD patients. In the next step, we were interested in analyzing what demographic and clinical characteristics in our PD patients are associated with a higher NAFLD occurrence. Presence of diabetes mellitus (DM), arterial hypertension (AH), dyslipidemia, body mass index > 25 kg/m(2), and daily glucose load > 100 g were associated with NAFLD occurrence. Peritoneal dialysis patients with NAFLD showed more carotid atherosclerosis than PD patients without NAFLD. In addition, CAP values (as indicator of liver steatosis) showed strong positive association with IMT (r = 0.801; p < 0.0001). Nonalcoholic fatty liver disease was a strong predictor of carotid atherosclerosis in PD patients. ♦ Conclusion: Nonalcoholic fatty liver disease is highly prevalent in PD patients. Peritoneal dialysis patients with NAFLD are at high risk of atherosclerosis. Assessment of NAFLD in PD patients may be helpful for CVD risk stratification. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPeritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Brojčani podacivol. 36, br. 4, str. 427-432
p-ISSN0896-8608
e-ISSN1718-4304
DOIhttps://doi.org/10.3747/pdi.2014.00223
URN:NBNurn:nbn:hr:184:938792
Datum objave publikacije2016-07-01
URL dokumentahttp://journals.sagepub.com/doi/10.3747/pdi.2014.00223
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2022-02-28 12:06:26
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