Aim: To present a series of cases of pediatric patients who have been tested positively to anti-SARS-CoV-2 IgG and who have developed multisystem inflammatory syndrome that occurred because of COVID19 infection. In its definition, it implies symptoms such as fever, signs affecting two or more organ systems, positive contact with the COVID19 virus while excluding other causes and describing the efficacy of applied immunosuppressive therapy. Case report: Four pediatric patients aged 18 months, 9, 10 and 15 years were referred to an emergency pediatric clinic because of the persistent fever and symptoms of various organ systems. In the case of four patients, three out of the four patients had vomiting, diarrhea, rash and conjunctivitis as their main symptoms, and in the case of the remaining patient, their symptoms were the impaired gait and weakened tendon reflexes of the legs. In all patients the laboratory findings confirmed acute inflammation, and due to elevated brain natriuretic peptide they underwent the cardiac processing. The ultrasound of the heart showed mitral regurgitation in two patients, and in one pericardial effusion. After the diagnoses — the multisystem inflammatory response, the therapy in the case of our patients was in line with the unofficial world 1 European guidelines. They were administered intravenously immunoglobulins 1 corticosteroids and fluid replacement as well as the vasoactive drugs. Given the fact, that in this way it is possible for the bacterial sepsis to present itself upon arrival — hemoculture broad-spectrum antibiotics were administered. All four patients have recovered and were released home. Conclusion: Timely detection and treatment of the multisystem inflammatory response also means a better outcome for the patient. Potential future research could focus on elucidating this condition and possible Ik long-term consequences, and thus prevent severe clinical images.