prikaz prve stranice dokumenta Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study
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Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study
Croatian medical journal, 60 (2019), 3; 227-236. urn:nbn:hr:184:867218
Hudetz, Damir; Borić, Igor; Rod, Eduard; Jelec, Željko; Kunovac, Barbara; Polašek, Ozren; Vrdoljak, Trpimir; Plečko, Mihovil; Skelin, Andrea; Polančec, Denis; Zenić, Lucija; Primorac, Dragan

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Hudetz, D., Borić, I., Rod, E., Jelec, Ž., Kunovac, B., Polašek, O. ... Primorac, D. (2019). Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study. Croatian medical journal, 60. (3), 227-236. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:867218

Hudetz, Damir, et al. "Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study." Croatian medical journal, vol. 60, br. 3, 2019, str. 227-236. https://urn.nsk.hr/urn:nbn:hr:184:867218

Hudetz, Damir, Igor Borić, Eduard Rod, Željko Jelec, Barbara Kunovac, Ozren Polašek, Trpimir Vrdoljak, et al. "Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study." Croatian medical journal 60, br. 3 (2019): 227-236. https://urn.nsk.hr/urn:nbn:hr:184:867218

Hudetz, D., et al. (2019) 'Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study', Croatian medical journal, 60(3), str. 227-236. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:867218 (Datum pristupa: 22.04.2024.)

Hudetz D, Borić I, Rod E, Jelec Ž, Kunovac B, Polašek O, i sur.. Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study. Croatian medical journal [Internet]. 2019. [pristupljeno 22.04.2024.];60(3):227-236. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:867218

D. Hudetz, et al., "Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study", Croatian medical journal, vol. 60, br. 3, str. 227-236, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:867218. [Citirano: 22.04.2024.]

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Naslov (engleski)Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study
AutorDamir Hudetz
AutorIgor Borić
AutorEduard Rod
AutorŽeljko Jelec
AutorBarbara Kunovac
AutorOzren Polašek
AutorTrpimir Vrdoljak
AutorMihovil Plečko
AutorAndrea Skelin
AutorDenis Polančec
AutorLucija Zenić
AutorDragan Primorac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Aim To analyze clinical and functional effects of intra-articular injection of autologous micro-fragmented lipoaspirate (MLA) in patients with late stage knee osteoarthritis (KOA). Secondary aims included classifying cell types contributing to the treatment effect, performing detailed MRI-based classification of KOA, and elucidating the predictors for functional outcomes. Methods This prospective, non-randomized study was conducted from June 2016 to February 2018 and enrolled 20 patients with late stage symptomatic KOA (Kellgren Lawrence grade III, n = 4 ; and IV, n = 16) who received an intra- articular injection of autologous MLA in the index knee joint. At baseline radiological KOA grade and MRI were assessed in order to classify the morphology of KOA changes. Stromal vascular fraction cells obtained from MLA samples were stained with antibodies specific for cell surface markers. Patients were evaluated at baseline and 12-months after treatment with visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee Injury and Osteoarthritis Outcome Score (KOOS). Results Three patients (15%) received a total knee replacement and were not followed up completely. Seventeen patients (85%) showed a substantial pattern of KOOS and WOMAC improvement, significant in all accounts. KOOS score improved from 46 to 176% when compared with baseline, WOMAC decreased from 40 to 45%, while VAS rating decreased from 54% to 82% (all P values were < 0.001). MLA contained endothelial progenitor cells, pericytes, and supra-adventitial adipose stromal cells as most abundant cell phenotypes. Conclusion This study is among the first to show a positive effect of MLA on patients with late stages KOA.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Rad s konferencije
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian medical journal
Brojčani podacivol. 60, br. 3, str. 227-236
p-ISSN0353-9504
URN:NBNurn:nbn:hr:184:867218
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1049705
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-02-17 14:01:59