prikaz prve stranice dokumenta Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial
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Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial
Experimental Biology and Medicine, (2020); 1-9. https://doi.org/10.1177/1535370220968752
Kraljević Pavelić, Sandra; Micek, Vedran; Bobinac, Dragica; Bazdulj, Edo; Gianoncelli, Alessandra; Krpan, Dalibor; Žuvić, Marta; Eisenwagen, Sandra; Stambrook, Peter J; Pavelić, Krešimir

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Kraljević Pavelić, S., Micek, V., Bobinac, D., Bazdulj, E., Gianoncelli, A., Krpan, D. ... Pavelić, K. (2020). Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial. Experimental Biology and Medicine, 1-9. doi: 10.1177/1535370220968752

Kraljević Pavelić, Sandra, et al. "Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial." Experimental Biology and Medicine, 2020, str. 1-9. https://doi.org/10.1177/1535370220968752

Kraljević Pavelić, Sandra, Vedran Micek, Dragica Bobinac, Edo Bazdulj, Alessandra Gianoncelli, Dalibor Krpan, Marta Žuvić, Sandra Eisenwagen, Peter J Stambrook i Krešimir Pavelić. "Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial." Experimental Biology and Medicine (2020): 1-9. https://doi.org/10.1177/1535370220968752

Kraljević Pavelić, S., et al. (2020) 'Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial', Experimental Biology and Medicine, str. 1-9. doi: 10.1177/1535370220968752

Kraljević Pavelić S, Micek V, Bobinac D, Bazdulj E, Gianoncelli A, Krpan D, i sur.. Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial. Experimental Biology and Medicine [Internet]. 12.11.2020. [pristupljeno 18.04.2024.];1-9. doi: 10.1177/1535370220968752

S. Kraljević Pavelić, et al., "Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial", Experimental Biology and Medicine, str. 1-9, Studeni 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:843902. [Citirano: 18.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:843902
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Naslov (engleski)Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial
AutorSandra Kraljević Pavelić
AutorVedran Micek
AutorDragica Bobinac
AutorEdo Bazdulj
AutorAlessandra Gianoncelli
AutorDalibor Krpan
AutorMarta Žuvić
AutorSandra Eisenwagen
AutorPeter J Stambrook
AutorKrešimir Pavelić
Autorova ustanovaSveučilište Jurja Dobrile u Puli
Autorova ustanovaSveučilište u Rijeci
Fakultet zdravstvenih studija
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		INTERDISCIPLINARNA PODRUČJA ZNANOSTI
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
Sažetak (engleski)
The severity of osteoporosis in humans manifests in its high incidence and by its complications that diminish quality of life. A societal consequence of osteoporosis is the substantial burden that it inflicts upon patients and their families. Several bone-modifying drugs have been prescribed to patients with osteoporosis. However, evidence for their anti-fracture efficacy remains inconclusive. To the contrary, long-term use of anti-osteoporotic drugs such as bisphosphonates and Denosumab, an RANKL inhibitor, have resulted in adverse events. We now present an alternative and adjuvant approach for treatment of osteoporosis. The data derive from in vivo studies in an ovariectomized rat model and from a randomized double blind, placebo-controlled human clinical study. Both studies involved treatment with Panaceo Micro Activation (PMA)-zeolite-clinoptilolite, a defined cation exchange clinoptilolite, which clearly improved all bone histomorphometric parameters examined from ovariectomized animals, indicative for increased bone formation. Moreover, intervention with PMA-zeolite-clinoptilolite for one year proved safe in humans. Furthermore, patients treated with PMA-zeolite-clinoptilolite showed an increase in bone mineral density, an elevated level of markers indicative of bone formation, a significant reduction in pain, and significantly improved quality of life compared with patients in the control (placebo) group. These encouraging positive effects of PMA-zeolite-clinoptilolite on bone integrity and on osteoporosis warrant further evaluation of treatment with PMA-zeolite-clinoptilolite as a new alternative adjuvant therapy for osteoporosis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaExperimental Biology and Medicine
Brojčani podacivol. 0, str. 1-9, 153537022096875
p-ISSN1535-3702
e-ISSN1535-3699
DOIhttps://doi.org/10.1177/1535370220968752
URN:NBNurn:nbn:hr:184:843902
Datum objave publikacije2020-11-12
URL dokumentahttp://journals.sagepub.com/doi/10.1177/1535370220968752
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2021-01-28 21:40:31