prikaz prve stranice dokumenta Activity of fosfomycin against nosocomial multiresistant bacterial pathogens from Croatia: a multicentric study
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Activity of fosfomycin against nosocomial multiresistant bacterial pathogens from Croatia: a multicentric study
Croatian Medical Journal, 59 (2018), 2; 56-64. https://doi.org/10.3325/cmj.2018.59.56
Bielen, Luka; Likić, Robert; Erdeljić, Viktorija; Mareković, Ivana; Firis, Nataša; Grgić-Medić, Marijana; Godan, Ana; Tomić, Ivan; Hunjak, Blaženka; Markotić, Alemka; Bejuk, Danijela; Tičić, Vladimira; Balzar, Silvana; Bedenić, Branka

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Bielen, L., Likić, R., Erdeljić, V., Mareković, I., Firis, N., Grgić Medić, M. ... Bedenić, B. (2018). Activity of fosfomycin against nosocomial multiresistant bacterial pathogens from Croatia: a multicentric study. Croatian Medical Journal, 59. (2), 56-64. doi: 10.3325/cmj.2018.59.56

Bielen, Luka, et al. "Activity of fosfomycin against nosocomial multiresistant bacterial pathogens from Croatia: a multicentric study." Croatian Medical Journal, vol. 59, br. 2, 2018, str. 56-64. https://doi.org/10.3325/cmj.2018.59.56

Bielen, Luka, Robert Likić, Viktorija Erdeljić, Ivana Mareković, Nataša Firis, Marijana Grgić Medić, Ana Godan, et al. "Activity of fosfomycin against nosocomial multiresistant bacterial pathogens from Croatia: a multicentric study." Croatian Medical Journal 59, br. 2 (2018): 56-64. https://doi.org/10.3325/cmj.2018.59.56

Bielen, L., et al. (2018) 'Activity of fosfomycin against nosocomial multiresistant bacterial pathogens from Croatia: a multicentric study', Croatian Medical Journal, 59(2), str. 56-64. doi: 10.3325/cmj.2018.59.56

Bielen L, Likić R, Erdeljić V, Mareković I, Firis N, Grgić Medić M, i sur.. Activity of fosfomycin against nosocomial multiresistant bacterial pathogens from Croatia: a multicentric study. Croatian Medical Journal [Internet]. 2018. [pristupljeno 24.02.2025.];59(2):56-64. doi: 10.3325/cmj.2018.59.56

L. Bielen, et al., "Activity of fosfomycin against nosocomial multiresistant bacterial pathogens from Croatia: a multicentric study", Croatian Medical Journal, vol. 59, br. 2, str. 56-64, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:836530. [Citirano: 24.02.2025.]

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Podaci o radu
Naslov (engleski)Activity of fosfomycin against nosocomial multiresistant bacterial pathogens from Croatia: a multicentric study
AutorLuka Bielen
MBZ: 301715
AutorRobert Likić
MBZ: 271762
AutorViktorija Erdeljić
AutorIvana Mareković
MBZ: 273090
AutorNataša Firis
AutorMarijana Grgić-Medić
AutorAna Godan
AutorIvan Tomić
AutorBlaženka Hunjak
MBZ: 242183
AutorAlemka Markotić
AutorDanijela Bejuk
MBZ: 176564
AutorVladimira Tičić
MBZ: 301412
AutorSilvana Balzar
AutorBranka Bedenić
MBZ: 178926
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za zarazne bolesti)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Aim To determine in vitro susceptibility of multiresistant bacterial isolates to fosfomycin. Methods In this prospective in vitro study (local non-random sample, level of evidence 3), 288 consecutively collected multiresistant bacterial isolates from seven medical centers in Croatia were tested from February 2014 until October 2016 for susceptibility to fosfomycin and other antibiotics according to Clinical and Laboratory Standards Institute methodology. Susceptibility to fosfomycin was... Više determined by agar dilution method, while disc diffusion was performed for in vitro testing of other antibiotics. Polymerase chain reaction and sequencing were performed for the majority of extended spectrum beta-lactamase (ESBL)- producing Klebsiella pneumoniae (K. pneumoniae) and carbapenem-resistant isolates. Results The majority of 288 multiresistant bacterial isolates (82.6%) were susceptible to fosfomycin. The 236 multiresistant Gram- negative isolates showed excellent susceptibility to fosfomycin. Susceptibility rates were as follows: Escherichia coli ESBL 97%, K. pneumoniae ESBL 80%, Enterobacter species 85.7%, Citrobacter freundii 100%, Proteus mirabilis 93%, and Pseudomonas aeruginosa 60%. Of the 52 multiresistant Gram- positive isolates, methicillin-resistant Staphylococcus aureus showed excellent susceptibility to fosfomycin (94.4%) and vancomycin-resistant enterococcus showed low susceptibility to fosfomycin (31%). Polymerase chain reaction analysis of 36/50 ESBL-producing K. pneumoniae isolates showed that majority of isolates had CTX-M-15 beta lactamase (27/36) preceded by ISEcp insertion sequence. All carbapenem-resistant Enterobacter and Citrobacter isolates had bla(VIM-1) metallo- beta-lactamase gene. Conclusion With the best in vitro activity among the tested antibiotics, fosfomycin could be an effective treatment option for infections caused by multiresistant Gram-negative and Gram-positive bacterial strains in the hospital setting Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 59, br. 2, str. 56-64
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2018.59.56
URN:NBNurn:nbn:hr:184:836530
Datum objave publikacije2018
URL dokumentahttp://bib.irb.hr/1050135
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-02-04 08:05:33
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