prikaz prve stranice dokumenta Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants
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Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants
Scientific Reports, 14 (2024), 1; 13605. https://doi.org/10.1038/s41598-024-64384-y
Maaß, Henrike; Ynga-Durand, Mario; Milošević, Marko; Krstanović, Fran; Matešić, Marina Pribanić; Žuža, Iva; Jonjić, Stipan; Brizić, Ilija; Šustić, Alan; Bloos, Frank; Marx, Gernot; Jaschinski, Ulrich; Reinhart, Konrad; Spies, Claudia; Reil, Lorenz; Putensen, Christian; Ragaller, Maximilian; Utzlino, Stefan; Mörer, Onnen; Gründling, Matthias; Kluge, Stefan; Nierhaus, Axel; Welte, Tobias; Bauer, Michael; Bloos, Frank; Ludwig, Katrin; Kiehntopf, Michael; Elke, Gunnar; Bogatsch, Holger; Engel, Christoph; Loeffler, Markus; Briegel, Josef; Kaufmann, Ines; John, Stefan; Riessen, Reimer; Meybohm, Patrick; Protić, Alen; Čičin-Šain, Luka Više autora...

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Maaß, H., Ynga Durand, M., Milošević, M., Krstanović, F., Matešić, M. P., Žuža, I. ... Čičin Šain, L. (2024). Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants. Scientific Reports, 14. (1). doi: 10.1038/s41598-024-64384-y

Maaß, Henrike, et al. "Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants." Scientific Reports, vol. 14, br. 1, 2024. https://doi.org/10.1038/s41598-024-64384-y

Maaß, Henrike, Mario Ynga Durand, Marko Milošević, Fran Krstanović, Marina Pribanić Matešić, Iva Žuža, Stipan Jonjić, et al. "Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants." Scientific Reports 14, br. 1 (2024). https://doi.org/10.1038/s41598-024-64384-y

Maaß, H., et al. (2024) 'Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants', Scientific Reports, 14(1). doi: 10.1038/s41598-024-64384-y

Maaß H, Ynga Durand M, Milošević M, Krstanović F, Matešić MP, Žuža I, i sur.. Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants. Scientific Reports [Internet]. 13.06.2024. [pristupljeno 10.04.2025.];14(1). doi: 10.1038/s41598-024-64384-y

H. Maaß, et al., "Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants", Scientific Reports, vol. 14, br. 1, Lipanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:830975. [Citirano: 10.04.2025.]

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Naslov (engleski)Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants
AutorHenrike Maaß
AutorMario Ynga-Durand
AutorMarko Milošević
AutorFran Krstanović
AutorMarina Pribanić Matešić
AutorIva Žuža
AutorStipan Jonjić
AutorIlija Brizić
AutorAlan Šustić
AutorFrank Bloos
AutorGernot Marx
AutorUlrich Jaschinski
AutorKonrad Reinhart
AutorClaudia Spies
AutorLorenz Reil
AutorChristian Putensen
AutorMaximilian Ragaller
AutorStefan Utzlino
AutorOnnen Mörer
AutorMatthias Gründling
AutorStefan Kluge
AutorAxel Nierhaus
AutorTobias Welte
AutorMichael Bauer
AutorFrank Bloos
AutorKatrin Ludwig
AutorMichael Kiehntopf
AutorGunnar Elke
AutorHolger Bogatsch
AutorChristoph Engel
AutorMarkus Loeffler
AutorJosef Briegel
AutorInes Kaufmann
AutorStefan John
AutorReimer Riessen
AutorPatrick Meybohm
AutorAlen Protić
AutorLuka Čičin-Šain
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Intenzivna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Abstract The aim of this study was to characterize the systemic cytokine signature of critically ill COVID-19 patients in a high mortality setting aiming to identify biomarkers of severity, and to explore their associations with viral loads and clinical characteristics. We studied two COVID-19 critically ill patient cohorts from a referral centre located in Central Europe. The cohorts were recruited during the pre-alpha/alpha (November 2020 to April 2021) and delta (end of 2021) period... Više respectively. We determined both the serum and bronchoalveolar SARS-CoV-2 viral load and identified the variant of concern (VoC) involved. Using a cytokine multiplex assay, we quantified systemic cytokine concentrations and analyzed their relationship with clinical findings, routine laboratory workup and pulmonary function data obtained during the ICU stay. Patients who did not survive had a significantly higher systemic and pulmonary viral load. Patients infected with the pre-alpha VoC showed a significantly lower viral load in comparison to those infected with the alpha- and delta-variants. Levels of systemic CTACK, M-CSF and IL-18 were significantly higher in non-survivors in comparison to survivors. CTACK correlated directly with APACHE II scores. We observed differences in lung compliance and the association between cytokine levels and pulmonary function, dependent on the VoC identified. An intra-cytokine analysis revealed a loss of correlation in the non-survival group in comparison to survivors in both cohorts. Critically ill COVID-19 patients exhibited a distinct systemic cytokine profile based on their survival outcomes. CTACK, M-CSF and IL-18 were identified as mortality-associated analytes independently of the VoC involved. The Intra-cytokine correlation analysis suggested the potential role of a dysregulated systemic network of inflammatory mediators in severe COVID-19 mortality. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 14, br. 1, 13605
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-024-64384-y
URN:NBNurn:nbn:hr:184:830975
Datum objave publikacije2024-06-13
ProjektŠifra: IP-CORONA-2020-04-2073
Naziv (hrvatski): Dosta skrivanja CoV-2: uspostava baze monoklonskih protutijela na SARS-Cov-2
Naziv (engleski): No more hiding CoV-2: Establishment of SARS-Cov-2 mAbeom
Kratica: CoV2mAbs
Voditelj: Ilija Brizić
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects - CORONA
URL dokumentahttps://www.nature.com/articles/s41598-024-64384-y
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-08-13 07:22:23
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