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Variation in antibiotic use among and within different settings: a systematic review
Journal of Antimicrobial Chemotherapy, 73 (2018), suppl_6; vi17-vi29. https://doi.org/10.1093/jac/dky115
Zanichelli, Veronica; Monnier, Annelie A; Gyssens, Inge C; Adriaenssens, Niels; Versporten, Ann; Pulcini, Céline; Le Maréchal, Marion; Tebano, Gianpiero; Vlahović-Palčevski, Vera; Stanić Benić, Mirjana; Milanič, Romina; Harbarth, Stephan; Hulscher, Marlies E; Huttner, Benedikt

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Zanichelli, V., Monnier, A. A., Gyssens, I. C., Adriaenssens, N., Versporten, A., Pulcini, C. ... Huttner, B. (2018). Variation in antibiotic use among and within different settings: a systematic review. Journal of Antimicrobial Chemotherapy, 73. (suppl_6), vi17-vi29. doi: 10.1093/jac/dky115

Zanichelli, Veronica, et al. "Variation in antibiotic use among and within different settings: a systematic review." Journal of Antimicrobial Chemotherapy, vol. 73, br. suppl_6, 2018, str. vi17-vi29. https://doi.org/10.1093/jac/dky115

Zanichelli, Veronica, Annelie A Monnier, Inge C Gyssens, Niels Adriaenssens, Ann Versporten, Céline Pulcini, Marion Le Maréchal, et al. "Variation in antibiotic use among and within different settings: a systematic review." Journal of Antimicrobial Chemotherapy 73, br. suppl_6 (2018): vi17-vi29. https://doi.org/10.1093/jac/dky115

Zanichelli, V., et al. (2018) 'Variation in antibiotic use among and within different settings: a systematic review', Journal of Antimicrobial Chemotherapy, 73(suppl_6), str. vi17-vi29. doi: 10.1093/jac/dky115

Zanichelli V, Monnier AA, Gyssens IC, Adriaenssens N, Versporten A, Pulcini C, i sur.. Variation in antibiotic use among and within different settings: a systematic review. Journal of Antimicrobial Chemotherapy [Internet]. 06.2018. [pristupljeno 25.02.2025.];73(suppl_6):vi17-vi29. doi: 10.1093/jac/dky115

V. Zanichelli, et al., "Variation in antibiotic use among and within different settings: a systematic review", Journal of Antimicrobial Chemotherapy, vol. 73, br. suppl_6, str. vi17-vi29, Lipanj 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:799472. [Citirano: 25.02.2025.]

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Naslov (engleski)Variation in antibiotic use among and within different settings: a systematic review
AutorVeronica Zanichelli
AutorAnnelie A Monnier
AutorInge C Gyssens
AutorNiels Adriaenssens
AutorAnn Versporten
AutorCéline Pulcini
AutorMarion Le Maréchal
AutorGianpiero Tebano
AutorVera Vlahović-Palčevski
AutorMirjana Stanić Benić
AutorRomina Milanič
AutorStephan Harbarth
AutorMarlies E Hulscher
AutorBenedikt Huttner
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za farmakologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Klinička farmakologija s toksikologijom
Sažetak (engleski)
Objectives: Variation in antibiotic use may reflect inappropriate use. We aimed to systematically describe the variation in measures for antibiotic use among settings or providers. This study was conducted as part of the innovative medicines initiative (IMI)-funded international project DRIVE-AB. Methods: We searched for studies published in MEDLINE from January 2004 to January 2015 reporting variation in measures for systemic antibiotic use (e.g. DDDs) in inpatient and outpatient settings.... Više The ratio between a study's reported maximumand minimumvalues of a given measure [maximum: minimumratio (MMR)] was calculated as a measure of variation. Similar measures were grouped into categories and when possible the overall median ratio and IQR were calculated. Results: One hundred and forty-three studies were included, of which 85 (59.4%) were conducted in Europe and 12 (8.4%) in low-to middle-income countries. Most studies described the variation in the quantity of antibiotic use in the inpatient setting (81/143, 56.6%), especially among hospitals (41/81, 50.6%). Themost frequentmeasure was DDDs with different denominators, reported in 23/81 (28.4%) inpatient studies and in 28/62 (45.2%) outpatient studies. For this measure, we found a median MMR of 3.7 (IQR 2.6-5.0) in 4 studies reporting antibiotic use in ICUs in DDDs/1000 patient-days and a median MMR of 2.3 (IQR 1.5-3.2) in 18 studies reporting outpatient antibiotic use in DDDs/1000 inhabitant-days. Substantial variationwas also identified in othermeasures. Conclusions: Our review confirms the large variation in antibiotic use even across similar settings and providers. Data from low-and middle-income countries are under-represented. Further studies should try to better elucidate reasons for the observed variation to facilitate interventions that reduce unwarranted practice variation. In addition, the heterogeneity of reported measures clearly shows that there is need for standardization. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Antimicrobial Chemotherapy
Brojčani podacivol. 73, br. suppl_6, str. vi17-vi29
p-ISSN0305-7453
e-ISSN1460-2091
DOIhttps://doi.org/10.1093/jac/dky115
URN:NBNurn:nbn:hr:184:799472
Datum objave publikacije2018-06
URL dokumentahttps://academic.oup.com/jac/article/73/suppl_6/vi17/5033626
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-10-18 21:07:26
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