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Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge
Clinical Pathology, 16 (2023); 1-7. https://doi.org/10.1177/2632010X221149978
Hadžisejdić, Ita; Klarica, Lucia; Babarović, Emina; Marijić, Blažen; Valković, Toni; Jonjić, Nives

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Hadžisejdić, I., Klarica, L., Babarović, E., Marijić, B., Valković, T. i Jonjić, N. (2023). Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge. Clinical Pathology, 16., 1-7. doi: 10.1177/2632010X221149978

Hadžisejdić, Ita, et al. "Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge." Clinical Pathology, vol. 16, 2023, str. 1-7. https://doi.org/10.1177/2632010X221149978

Hadžisejdić, Ita, Lucia Klarica, Emina Babarović, Blažen Marijić, Toni Valković i Nives Jonjić. "Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge." Clinical Pathology 16 (2023): 1-7. https://doi.org/10.1177/2632010X221149978

Hadžisejdić, I., et al. (2023) 'Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge', Clinical Pathology, 16, str. 1-7. doi: 10.1177/2632010X221149978

Hadžisejdić I, Klarica L, Babarović E, Marijić B, Valković T, Jonjić N. Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge. Clinical Pathology [Internet]. 15.01.2023. [pristupljeno 06.05.2024.];16:1-7. doi: 10.1177/2632010X221149978

I. Hadžisejdić, L. Klarica, E. Babarović, B. Marijić, T. Valković i N. Jonjić, "Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge", Clinical Pathology, vol. 16, str. 1-7, Siječanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:742536. [Citirano: 06.05.2024.]

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Naslov (engleski)Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge
AutorIta Hadžisejdić
AutorLucia Klarica
AutorEmina Babarović
AutorBlažen Marijić
AutorToni Valković
AutorNives Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Non-Hodgkin lymphomas are most frequently classified based on the lineage marker expression. However, lymphomas with aberrant marker expression as well as monoclonal IgH/IgΚ and TCR gene rearrangements may co-exist which can be misleading and confusing. Primary CD20 negative diffuse large B-cell lymphomas (DLBCL) represent a rare entity, and they account for 1% to 3% of cases. However, some CD20 negative DLBCLs could not be classified into known variants, creating both diagnostic and therapeutic dilemma’s. Primary CD20 negative DLBCL are more likely to have a non-germinal centre subtype, a higher proliferation index, more frequent extra-nodal involvement, a poorer response, and poorer prognosis to conventional treatment compared to CD20 positive DLBCL. A 66- year-old postmenopausal lady, presented with palpable, bilateral neck lymphadenopathy and difficulty swallowing. She also had left leg lymphoedema, poor appetited, fatigue and weight loss. Her symptoms lasted approximately 1 month. After histological, immunohistochemical and clonality analysis of the lymph node the patient was diagnosed with primary nodal CD20 and PAX-5 negative DLBCL with dual immunoglobulin light-chain kappa ( IgK) and T-cell receptor ( TCR) gene rearrangement. This unusual and unique case presented a diagnostic challenge because it was CD20 and PAX-5 negative, had dual IgK and TCR gene rearrangement and, it could not be classified within the known and well established CD20 negative DLBCL variants. Describing such cases emphasises the fact that lymphomas unclassifiable within known variants of CD20 negative DLBCL do exist and that range and heterogeneity of CD20 negative DLBCL continues to evolve, and pathologist should be aware of these uncommon, atypical mature B-cell neoplasms.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Prikaz slučaja
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical Pathology
Brojčani podacivol. 16, str. 1-7
p-ISSN2632-010X
e-ISSN2632-010X
DOIhttps://doi.org/10.1177/2632010X221149978
URN:NBNurn:nbn:hr:184:742536
Datum objave publikacije2023-01-15
URL dokumentahttp://journals.sagepub.com/doi/10.1177/2632010X221149978
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-05-04 10:19:27