Introduction: The presence of an injury, in addition to physical, can also impair psychological health. Depression, anxiety and stress are difficulties that arise as a result of impaired health status. In addition to injury, SARS-CoV-2 virus also adversely affects the clinical picture of psychological health. Aim: The main objective of the study was to examine the level of depression, anxiety and stress in persons on physical rehabilitation after suffering an injury. Additionally, the association of sociodemographic characteristics, injury characteristics, and SARS-CoV-2 virus exposure with mental health measures was examined. Method: A total of 55 patients in the physical rehabilitation procedure participated in the cross-sectional study, of which 27 were men and 28 were women. The average age of the respondents was 56.4 years, most of them had secondary education (76.4%), were in a partnership (74.5%) and 43.6% were employed and 40% were retired. Participants completed the following self-assessment questionnaires: the Sociodemographic Questionnaire, the Depression, Anxiety, and Stress Scale (DASS-21), the Modified Health Status Questionnaire (SF-36), and the Short Questionnaire on COVID-19 Disease Exposure. Results: The majority of respondents had injured one part of the body (89.1%), with the most common types of injury being an artificial joint (32.7%) and muscle damage (29.1%). 7.3% of respondents had a significant risk for depression, 16.4% for anxiety and 4.4% for stress. Female gender, leg injury, artificial hip and lower back injury were significantly associated with poorer mental health outcomes while retiree status was associated with lower levels of depression. People with who have experienced COVID-19 and or who’s close ones were positive for COVID-those have significantly higher levels of psychological difficulties examined. Significant independent predictors of depression and anxiety are personal exposure to COVID-19 disease and implantation of an artificial joint. Additionally, a significant predictor of anxiety is physical limitation due to injury. The only significant predictor of stress is the implantation of an artificial joint. Conclusion: Results of the study indicate good mental health of persons in physical rehabilitation after experiencing one or more physical injuries. The COVID-19 pandemic has a significant impact on mental health an in clinical work it is necessary to increase the sensitivity to its’ impact on patients in physical rehabilitation. Particularly at risk are people with a built-in artificial hook.