prikaz prve stranice dokumenta Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice
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Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice
Archives of Medical Research, 36 (2005), 4; 339-343. https://doi.org/10.1016/j.arcmed.2005.03.005
Muhvić Urek, Miranda; Bralić, Marina; Tomac, Jelena; Borčić, Josipa; Uhač, Ivone; Glažar, Irena; Antonić, Robert; Ferreri, Silvio

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Muhvić Urek, M., Bralić, M., Tomac, J., Borčić, J., Uhač, I., Glažar, I. ... Ferreri, S. (2005). Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice. Archives of Medical Research, 36. (4), 339-343. doi: 10.1016/j.arcmed.2005.03.005

Muhvić Urek, Miranda, et al. "Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice." Archives of Medical Research, vol. 36, br. 4, 2005, str. 339-343. https://doi.org/10.1016/j.arcmed.2005.03.005

Muhvić Urek, Miranda, Marina Bralić, Jelena Tomac, Josipa Borčić, Ivone Uhač, Irena Glažar, Robert Antonić i Silvio Ferreri. "Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice." Archives of Medical Research 36, br. 4 (2005): 339-343. https://doi.org/10.1016/j.arcmed.2005.03.005

Muhvić Urek, M., et al. (2005) 'Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice', Archives of Medical Research, 36(4), str. 339-343. doi: 10.1016/j.arcmed.2005.03.005

Muhvić Urek M, Bralić M, Tomac J, Borčić J, Uhač I, Glažar I, i sur.. Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice. Archives of Medical Research [Internet]. 2005. [pristupljeno 14.04.2024.];36(4):339-343. doi: 10.1016/j.arcmed.2005.03.005

M. Muhvić Urek, et al., "Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice", Archives of Medical Research, vol. 36, br. 4, str. 339-343, 2005. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:731180. [Citirano: 14.04.2024.]

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Naslov (engleski)Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice
AutorMiranda Muhvić Urek
AutorMarina Bralić
AutorJelena Tomac
AutorJosipa Borčić
AutorIvone Uhač
AutorIrena Glažar
AutorRobert Antonić
AutorSilvio Ferreri
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Background: Radiotherapy for head and neck cancers causes permanent salivary gland dysfunction and xerostomia. The aim of this study was to determine changes in mice submandibular glands after X-irradiation. Methods: The submandibular glands of male C57BL/6 mice were locally X-irradiated in the head and neck region with a single dose of 7.5 or 15 Gy and analyzed morphologically and morphometrically at 1, 3, 6, 10, 40, and 90 days after irradiation. Results: Two phases of gland reaction to irradiation have been noted. The first, early phase is observed up to 10 days after irradiation. The second, late phase was observed 90 days after irradiation. Also, a dose-related effect was noticed. The most prominent morphological changes were pyknotic nuclei, vacuolization of acinar cells and lysis of acini and granular convoluted tubules. Changes were detected at 3 and 6 days after irradiation followed by tissue regeneration. Ninety days after irradiation, prominent pathological changes (vacuolization and pyknotic nuclei of acinar cells, lysis of acini and granular convoluted tubules and edema) were detected, but the most remarkable change was disseminated mononuclear infiltration. Also, a statistically significant reduction in number of acinar cells was detected in both irradiated glands. Conclusions: Occurrence of disseminated mononuclear infiltration in gland during late post-irradiation phase makes the mouse model potentially better than the rat model for investigation of irradiation-induced salivary gland damage.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaArchives of Medical Research
Brojčani podacivol. 36, br. 4, str. 339-343
p-ISSN0188-4409
DOIhttps://doi.org/10.1016/j.arcmed.2005.03.005
URN:NBNurn:nbn:hr:184:731180
Datum objave publikacije2005
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0188440905000470
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-18 14:08:41