prikaz prve stranice dokumenta Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events
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Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events
Clinical Kidney Journal, 10 (2017), 6; 852-858. https://doi.org/10.1093/ckj/sfx050
Katalinić, Nataša; Starčević, Alma; Mavrinac, Martina; Balen, Sanja

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Katalinić, N., Starčević, A., Mavrinac, M. i Balen, S. (2017). Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events. Clinical Kidney Journal, 10. (6), 852-858. doi: 10.1093/ckj/sfx050

Katalinić, Nataša, et al. "Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events." Clinical Kidney Journal, vol. 10, br. 6, 2017, str. 852-858. https://doi.org/10.1093/ckj/sfx050

Katalinić, Nataša, Alma Starčević, Martina Mavrinac i Sanja Balen. "Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events." Clinical Kidney Journal 10, br. 6 (2017): 852-858. https://doi.org/10.1093/ckj/sfx050

Katalinić, N., et al. (2017) 'Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events', Clinical Kidney Journal, 10(6), str. 852-858. doi: 10.1093/ckj/sfx050

Katalinić N, Starčević A, Mavrinac M, Balen S. Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events. Clinical Kidney Journal [Internet]. 12.2017. [pristupljeno 16.04.2024.];10(6):852-858. doi: 10.1093/ckj/sfx050

N. Katalinić, A. Starčević, M. Mavrinac i S. Balen, "Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events", Clinical Kidney Journal, vol. 10, br. 6, str. 852-858, Prosinac 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:698119. [Citirano: 16.04.2024.]

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Naslov (engleski)Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events
AutorNataša Katalinić
AutorAlma Starčević
AutorMartina Mavrinac
AutorSanja Balen
MBZ: 236875
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kliničko-laboratorijsku dijagnostiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku informatiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Background: The aim of this study was to determine the frequency of exposure to different sensitizing events (SEs) and to assess their effects on human leucocyte antigen (HLA) alloimmunization in transplant candidates using two different HLA antibody screening techniques: complement-dependent cytotoxicity (CDC) and Luminex. Methods: This retrospective study included HLA antibody screening results for 163 patients on the kidney transplant waiting list (WL) tested from March 2012 until the end of December 2015 at the Tissue Typing Laboratory, Rijeka, Croatia. All sera samples were tested using the CDC and Luminex techniques in parallel. Results: Two-thirds of the patients [114 (70%)] on the WL were exposed to transfusions, pregnancies and/or kidney transplant. The pre-transplant sera of 104 (63.80%) patients were negative for antibodies. In the sera of 23 (14.11%) patients, HLA antibodies were detected by CDC and Luminex and in the sera of 36 (22.09%) patients by Luminex only. Conclusion: In patients on kidney WL, previous organ transplantation represents the strongest immunogenic stimulus, followed by blood transfusions (the most frequent SE) and pregnancies. Although Luminex is more sensitive than CDC in HLA antibody detection, the decision on unacceptable HLA antigens in WL patients has to be based on the results of both assays and the patient’s immunization history.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical Kidney Journal
Brojčani podacivol. 10, br. 6, str. 852-858
p-ISSN2048-8505
e-ISSN2048-8513
DOIhttps://doi.org/10.1093/ckj/sfx050
URN:NBNurn:nbn:hr:184:698119
Datum objave publikacije2017-12
Datum objave publikacije2017-12-01
Datum objave publikacije2017-07-25
URL dokumentahttp://academic.oup.com/ckj/article/10/6/852/4036278
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2018-12-04 11:33:39