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SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes
Viruses, 14 (2022), 6; 1292. https://doi.org/10.3390/v14061292
Ynga-Durand, Mario; Maaß, Henrike; Milošević, Marko; Krstanović, Fran; Pribanić Matešić, Marina; Jonjić, Stipan; Protić, Alen; Brizić, Ilija; Šustić, Alan; Čičin-Šain, Luka

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Ynga Durand, M., Maaß, H., Milošević, M., Krstanović, F., Pribanić Matešić, M., Jonjić, S. ... Čičin Šain, L. (2022). SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes. Viruses, 14. (6). doi: 10.3390/v14061292

Ynga Durand, Mario, et al. "SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes." Viruses, vol. 14, br. 6, 2022. https://doi.org/10.3390/v14061292

Ynga Durand, Mario, Henrike Maaß, Marko Milošević, Fran Krstanović, Marina Pribanić Matešić, Stipan Jonjić, Alen Protić, Ilija Brizić, Alan Šustić i Luka Čičin Šain. "SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes." Viruses 14, br. 6 (2022). https://doi.org/10.3390/v14061292

Ynga Durand, M., et al. (2022) 'SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes', Viruses, 14(6). doi: 10.3390/v14061292

Ynga Durand M, Maaß H, Milošević M, Krstanović F, Pribanić Matešić M, Jonjić S, i sur.. SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes. Viruses [Internet]. 14.06.2022. [pristupljeno 13.04.2024.];14(6). doi: 10.3390/v14061292

M. Ynga Durand, et al., "SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes", Viruses, vol. 14, br. 6, Lipanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:689251. [Citirano: 13.04.2024.]

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Podaci o radu
Naslov (engleski)SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes
AutorMario Ynga-Durand
AutorHenrike Maaß
AutorMarko Milošević
AutorFran Krstanović
AutorMarina Pribanić Matešić
AutorStipan Jonjić
AutorAlen Protić
AutorIlija Brizić
AutorAlan Šustić
AutorLuka Čičin-Šain
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Intenzivna medicina
Sažetak (engleski)
While SARS-CoV-2 detection in sputum and swabs from the upper respiratory tract has been used as a diagnostic tool, virus quantification showed poor correlation to disease outcome and thus, poor prognostic value. Although the pulmonary compartment represents a relevant site for viral load analysis, limited data exploring the lower respiratory tract is available, and its association to clinical outcomes is relatively unknown. Using bronchoalveolar lavage (BAL) and serum samples, we quantified SARS-CoV-2 copy numbers in the pulmonary and systemic compartments of critically ill patients admitted to the intensive care unit of a COVID-19 referral hospital in Croatia during the second and third pandemic waves. Clinical data, including 30-day survival after ICU admission, were included. We found that elevated SARS-CoV-2 copy numbers in both BAL and serum samples were associated with fatal outcomes. Remarkably, the highest and earliest viral loads after initiation of mechanical ventilation support were increased in the non-survival group. Our results imply that viral loads in the lungs contribute to COVID-19 disease severity, while blood titers correlate with lung virus titers, albeit at a lower level. Moreover, they suggest that BAL SARS-CoV-2 copy number quantification at ICU admission may provide a predictive parameter of clinical COVID-19 outcomes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaViruses
Brojčani podacivol. 14, br. 6, 1292
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v14061292
URN:NBNurn:nbn:hr:184:689251
Datum objave publikacije2022-06-14
ProjektŠifra: IP-CORONA-2020-04-2073
Naziv (hrvatski): Dosta skrivanja CoV-2: uspostava baze monoklonskih protutijela na SARS-Cov-2
Naziv (engleski): No more hiding CoV-2: Establishment of SARS-Cov-2 mAbeom
Kratica: CoV2mAbs
Voditelj: Ilija Brizić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP-CORONA
URL dokumentahttps://www.mdpi.com/1999-4915/14/6/1292
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-07-06 06:54:13