prikaz prve stranice dokumenta Can inflammatory markers and clinical indices serve as useful referral criteria for leukocyte scan with inflammatory bowel disease?
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Can inflammatory markers and clinical indices serve as useful referral criteria for leukocyte scan with inflammatory bowel disease?
Nuclear Medicine Review, 23 (2020), 1; 15-20. https://doi.org/10.5603/NMR.a2020.0002
Klarica Gembić, Tihana; Kustić, Domagoj; Vukšić, Josipa; Huić, Dražen

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Klarica Gembić, T., Kustić, D., Vukšić, J. i Huić, D. (2020). Can inflammatory markers and clinical indices serve as useful referral criteria for leukocyte scan with inflammatory bowel disease?. Nuclear Medicine Review, 23. (1), 15-20. doi: 10.5603/NMR.a2020.0002

Klarica Gembić, Tihana, et al. "Can inflammatory markers and clinical indices serve as useful referral criteria for leukocyte scan with inflammatory bowel disease?." Nuclear Medicine Review, vol. 23, br. 1, 2020, str. 15-20. https://doi.org/10.5603/NMR.a2020.0002

Klarica Gembić, Tihana, Domagoj Kustić, Josipa Vukšić i Dražen Huić. "Can inflammatory markers and clinical indices serve as useful referral criteria for leukocyte scan with inflammatory bowel disease?." Nuclear Medicine Review 23, br. 1 (2020): 15-20. https://doi.org/10.5603/NMR.a2020.0002

Klarica Gembić, T., et al. (2020) 'Can inflammatory markers and clinical indices serve as useful referral criteria for leukocyte scan with inflammatory bowel disease?', Nuclear Medicine Review, 23(1), str. 15-20. doi: 10.5603/NMR.a2020.0002

Klarica Gembić T, Kustić D, Vukšić J, Huić D. Can inflammatory markers and clinical indices serve as useful referral criteria for leukocyte scan with inflammatory bowel disease?. Nuclear Medicine Review [Internet]. 2020. [pristupljeno 08.04.2025.];23(1):15-20. doi: 10.5603/NMR.a2020.0002

T. Klarica Gembić, D. Kustić, J. Vukšić i D. Huić, "Can inflammatory markers and clinical indices serve as useful referral criteria for leukocyte scan with inflammatory bowel disease?", Nuclear Medicine Review, vol. 23, br. 1, str. 15-20, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:686006. [Citirano: 08.04.2025.]

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Naslov (engleski)Can inflammatory markers and clinical indices serve as useful referral criteria for leukocyte scan with inflammatory bowel disease?
AutorTihana Klarica Gembić
AutorDomagoj Kustić
AutorJosipa Vukšić
AutorDražen Huić
MBZ: 182300
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za nuklearnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Nuklearna medicina
Sažetak (engleski)
BACKGROUND: In the follow-up of patients with inflammatory bowel disease (IBD), Tc-99m-HMPAO labelled leukocytes scintigraphy (leukocyte scan ; LS) has long been established as a valuable diagnostic tool. The aim of this study was to estimate the relationship between scintigraphic results, inflammatory markers (IM) (including white blood cells (WBCs) and C-reactive protein (CRP)), clinical parameters and clinical indices of the disease activity (CI), in order to determine clinical settings in... Više which LS is indicated. MATERIAL AND METHODS: A total of 147 patients who underwent LS, (79 males, 68 females, median age 36), were examined from April 2010 until December 2017 at the University Hospital Centre Zagreb, Croatia. Among these, 126 (86%) had Crohn’s disease (CD), and 21 (14%) had ulcerative colitis (UC). Either increased IM (either WBCs ≥ 10x109/L and/or CRP ≥ 7.4 mg/L) and/or CI, Crohn’s disease activity index (CDAI) score ≥ 220 points, Harvey-Bradshaw index (HBI) score ≥ 8 points, and severe colitis defined according to Truelove and Witts’ criteria (TWC) for UC, respectively, were considered consistent with active disease. RESULTS: Eighty-two patients (56%) had negative scans, while in 65 (44%) the scans were positive. Positive correlations were found between LS and all of the three parameters, WBCs, CRP and CI. When combined, the three parameters demonstrated even stronger positive correlation with the LS results with the correlation coefficient 0.76 (p < 0.0001, 95% CI 0.68–0.82). Using endoscopy and histological study findings of the obtained specimens as a composite reference standard, the overall sensitivity, specificity, positive predictive value and negative predictive value of IM and CI for LS were determined, being 91%, 85%, 83%, and 92%, respectively. IM and CI were both negative in 76 (52%) out of the total subjects. Of these, 70 had negative LS as well. CONCLUSIONS: In the presence of normal IM (WBCs < 10 × 109/L and CRP < 7.4 mg/L) with CI indicating no active or mildly active disease, LS is not necessarily indicated. Clinical parameters individually are not sufficient in defining accurate criteria for performing LS. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNuclear Medicine Review
Brojčani podacivol. 23, br. 1, str. 15-20
p-ISSN1506-9680
DOIhttps://doi.org/10.5603/NMR.a2020.0002
URN:NBNurn:nbn:hr:184:686006
Datum objave publikacije2020
URL dokumentahttp://bib.irb.hr/1070056
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-08 16:27:36
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