Skup podataka
Quantitative and qualitative variations of TILs in risk stratification and patient selection for neoadjuvant chemotherapy of luminal B and triple negative breast cancer immunophenotype
Medicinski fakultet, 2025. urn:nbn:hr:184:637606
Avirović, Manuela

 Skup podataka
Skup podataka: tils_in_lbbc_and_tnbc_nact.xlsx, 220.23 KB
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Opis datoteke:
Retrospektivno sakupljeni anonimizirani klinički podatci, iz računalne baze podataka Zavoda za patologiju - Vegasoft i iz Informatičkog bolničkog sustava - IBIS. Baza podataka koja se koristila u navedenom originalnom istraživanju uz odobrenje Etičkog povjerenstva KBC-a Rijeka (2170-29-02/1-19-2) za prikupljanje i obradu. (hrvatski)
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Avirović, M. (2025). Quantitative and qualitative variations of TILs in risk stratification and patient selection for neoadjuvant chemotherapy of luminal B and triple negative breast cancer immunophenotype [Skup podataka]. https://urn.nsk.hr/urn:nbn:hr:184:637606.

Avirović, Manuela. Quantitative and qualitative variations of TILs in risk stratification and patient selection for neoadjuvant chemotherapy of luminal B and triple negative breast cancer immunophenotype. Medicinski fakultet, 2025. 09.04.2025. https://urn.nsk.hr/urn:nbn:hr:184:637606.

Avirović, Manuela. 2025. Quantitative and qualitative variations of TILs in risk stratification and patient selection for neoadjuvant chemotherapy of luminal B and triple negative breast cancer immunophenotype. Medicinski fakultet. https://urn.nsk.hr/urn:nbn:hr:184:637606.

Avirović, M. 2025. Quantitative and qualitative variations of TILs in risk stratification and patient selection for neoadjuvant chemotherapy of luminal B and triple negative breast cancer immunophenotype. Medicinski fakultet. [Online]. [Citirano 09.04.2025.]. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:637606.

Avirović M. Quantitative and qualitative variations of TILs in risk stratification and patient selection for neoadjuvant chemotherapy of luminal B and triple negative breast cancer immunophenotype. [Internet]. Medicinski fakultet: Braće Branchetta 20, Rijeka, HR; 2025, [pristupljeno 09.04.2025.] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:637606.

M. Avirović, Quantitative and qualitative variations of TILs in risk stratification and patient selection for neoadjuvant chemotherapy of luminal B and triple negative breast cancer immunophenotype, Medicinski fakultet, 2025. Citirano: 09.04.2025. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:637606.

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:637606
Naslov (engleski)Quantitative and qualitative variations of TILs in risk stratification and patient selection for neoadjuvant chemotherapy of luminal B and triple negative breast cancer immunophenotype
AutorManuela Avirović
Sveučilište u Rijeci, Medicinski fakultet
SuradnikAna Car Peterko (Other)
KBC Rijeka; Medicinski fakultet Sveučilište u Rijeci
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Luminal B breast cancer (LBBC) represents an aggressive, high-grade ER+ disease, associated with a high proliferation rate of tumor cells, higher mutation burden and higher probability of eliciting the immune response. Clinical and pathological data from 89 patients of stage II-III, triple-negative(TN) and luminal B-like BC(LB-like BC) were included in the analysis. All patients were submitted to neoadjuvant chemotherapy (NACT). Quantitative and qualitative evaluation of TILs was performed on... Više tissue microarrays constructed from pretreatment core-needle biopsy tumor specimens. The proportion of stromal TILs, CD8, CD4 and PD-L1 positive(+) immune cells (IC), as well as the number of FOXP3, CTLA4 and HSP-70+IC was observed concerning tumor immunophenotype, traditional clinicopathological prognostic factors and tumor response to NACT. There was no statistically significant difference in the proportion of stromal TILs between LB-like and TNBC (P=0.344) cohorts. However, a higher CD4/CD8 ratio was associated with the TNBC biology (P=0.018) and within the LB-like BC cohort with high proliferation index and metastatic nodal involvement (P=0.045, P=0.015). Within the LB-like BC cohort, a higher expression of PD-L1 and HSP70+IC was associated with high proliferation index of tumor cells (P=0.018, P=0.040), massive metastatic nodal involvement (P=0.002, P=0.026) and higher stages of disease (P=0.004, P=0.042). Better response to NACT was associated with higher number of HSP70+IC and a higher proportion of CD8+ cells within LB-like BC cohort (P=0.045, P=0.012). Routine evaluation of immune markers and HSP70 may help identify high-risk patients of LB-like breast cancer who would have a better response to NACT. Sakrij dio sažetka
Metodologija (hrvatski)Nakon što se pregledom informatičkih baza podataka, Vegasoft i IBIS, pronađu slučajevi prema uključnim kriterijima istraživanja, sirovi podaci se pohranjuju na odvojenu i zaštićenu lokaciju od lokacije radnih verzija istraživačkih podataka. Podaci će se obraditi i pripremiti za statističku analizu.
Ključne riječi (hrvatski)
Jezikhrvatski
URN:NBNurn:nbn:hr:184:637606
Datum objave2025-01-20
GeolokacijaBraće Branchetta 20, Rijeka, Hrvatska
ProjektŠifra: uniri-biomed-18-259 1428
Naziv (hrvatski): Predictive and prognostic role of immune system cells, PD-1, PDL-1 and heat shock proteins in patients with triple negative, HER-2 positive and neoadjuvant treated breast cancer
Kratica: uniri-biomed-18-259 1428
Voditelj: Manuela Avirović
IzdavačMedicinski fakultet
Faculty of Medicine
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2025-01-19 06:59:29
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