prikaz prve stranice dokumenta Effect of Dexmedetomidine on Cardiopulmonary Bypass Induced Inflammatory Response in Patients Undergoing Aortic Valve Replacement
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Effect of Dexmedetomidine on Cardiopulmonary Bypass Induced Inflammatory Response in Patients Undergoing Aortic Valve Replacement
Life, 15 (2025), 4; 524. https://doi.org/10.3390/life15040524
Šafarić Oremuš, Zrinka; Bradić, Nikola; Gospić, Ivan; Presečki, Ivana; Sakan, Sanja; Sojčić, Nataša; Oremuš, Krešimir; Barić, Davor; Sotošek, Vlatka; Rudež, Igor

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Šafarić Oremuš, Z., Bradić, N., Gospić, I., Presečki, I., Sakan, S., Sojčić, N. ... Rudež, I. (2025). Effect of Dexmedetomidine on Cardiopulmonary Bypass Induced Inflammatory Response in Patients Undergoing Aortic Valve Replacement. Life, 15. (4). doi: 10.3390/life15040524

Šafarić Oremuš, Zrinka, et al. "Effect of Dexmedetomidine on Cardiopulmonary Bypass Induced Inflammatory Response in Patients Undergoing Aortic Valve Replacement." Life, vol. 15, br. 4, 2025. https://doi.org/10.3390/life15040524

Šafarić Oremuš, Zrinka, Nikola Bradić, Ivan Gospić, Ivana Presečki, Sanja Sakan, Nataša Sojčić, Krešimir Oremuš, Davor Barić, Vlatka Sotošek i Igor Rudež. "Effect of Dexmedetomidine on Cardiopulmonary Bypass Induced Inflammatory Response in Patients Undergoing Aortic Valve Replacement." Life 15, br. 4 (2025). https://doi.org/10.3390/life15040524

Šafarić Oremuš, Z., et al. (2025) 'Effect of Dexmedetomidine on Cardiopulmonary Bypass Induced Inflammatory Response in Patients Undergoing Aortic Valve Replacement', Life, 15(4). doi: 10.3390/life15040524

Šafarić Oremuš Z, Bradić N, Gospić I, Presečki I, Sakan S, Sojčić N, i sur.. Effect of Dexmedetomidine on Cardiopulmonary Bypass Induced Inflammatory Response in Patients Undergoing Aortic Valve Replacement. Life [Internet]. 22.03.2025. [pristupljeno 14.04.2025.];15(4). doi: 10.3390/life15040524

Z. Šafarić Oremuš, et al., "Effect of Dexmedetomidine on Cardiopulmonary Bypass Induced Inflammatory Response in Patients Undergoing Aortic Valve Replacement", Life, vol. 15, br. 4, Ožujak 2025. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:635721. [Citirano: 14.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:635721
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Naslov (engleski)Effect of Dexmedetomidine on Cardiopulmonary Bypass Induced Inflammatory Response in Patients Undergoing Aortic Valve Replacement
AutorZrinka Šafarić Oremuš
AutorNikola Bradić
AutorIvan Gospić
AutorIvana Presečki
AutorSanja Sakan
AutorNataša Sojčić
AutorKrešimir Oremuš
AutorDavor Barić
AutorVlatka Sotošek
AutorIgor Rudež
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Anesteziologija i reanimatologija
Sažetak (engleski)
Surgical aortic valve replacement (SAVR) remains an essential treatment option for patients with aortic stenosis (AS). Open-heart surgery requires the use of cardiopulmonary bypass (CPB), which triggers an inflammatory response that can lead to end-organ dysfunction and severe complications. Dexmedetomidine, a highly selective α2-adrenergic agonist, is widely used in anesthesia and intensive care medicine for its sedative, analgesic, and sympatholytic properties. This study aimed to investigate... Više whether dexmedetomidine exerts a clinically relevant anti-inflammatory effect in patients undergoing open-heart surgery and to determine the optimal dose. A prospective, double-blind, placebo-controlled study was conducted, including 60 patients randomized into three groups according to dexmedetomidine dose. Inflammatory markers (IL-6, TNF-α), renal function, and other clinical parameters were analyzed at multiple time points. Statistical analyses were performed to assess differences between the groups. Dexmedetomidine administration significantly affected TNF-α levels 12 h after CPB (p = 0.033), while previously reported suppression of IL-6 was not observed. Dexmedetomidine was associated with lower opioid consumption before extubation and showed a tendency to reduce postoperative delirium. Diuresis was significantly increased on the first postoperative day in dexmedetomidine-treated patients (p = 0.003), with no significant changes in other renal parameters. The incidence of atrial fibrillation was highest in the control group and lowest in the high-dose dexmedetomidine group, though this difference was not statistically significant. These results suggest that dexmedetomidine influences inflammatory and clinical outcomes; however, further research is needed to confirm its long-term benefits and optimal dosing strategies. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaLife
Brojčani podacivol. 15, br. 4, 524
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life15040524
URN:NBNurn:nbn:hr:184:635721
Datum objave publikacije2025-03-22
URL dokumentahttps://www.mdpi.com/2075-1729/15/4/524
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-25 07:58:21
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