prikaz prve stranice dokumenta Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection
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Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection
Cell Host & Microbe, 13 (2013), 5; 535-545. https://doi.org/10.1016/j.chom.2013.04.007
Jordan, Stefan; Ruzsics, Zsolt; Mitrović, Maja; Baranek, Thomas; Arapović, Jurica; Krmpotić, Astrid; Vivier, Eric; Dalod, Marc; Jonjić, Stipan; Dölken, Lars; Koszinowski, Ulrich H.

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Jordan, S., Ruzsics, Z., Mitrović, M., Baranek, T., Arapović, J., Krmpotić, A. ... Koszinowski, U. (2013). Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection. Cell Host & Microbe, 13. (5), 535-545. doi: 10.1016/j.chom.2013.04.007

Jordan, Stefan, et al. "Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection." Cell Host & Microbe, vol. 13, br. 5, 2013, str. 535-545. https://doi.org/10.1016/j.chom.2013.04.007

Jordan, Stefan, Zsolt Ruzsics, Maja Mitrović, Thomas Baranek, Jurica Arapović, Astrid Krmpotić, Eric Vivier, et al. "Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection." Cell Host & Microbe 13, br. 5 (2013): 535-545. https://doi.org/10.1016/j.chom.2013.04.007

Jordan, S., et al. (2013) 'Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection', Cell Host & Microbe, 13(5), str. 535-545. doi: 10.1016/j.chom.2013.04.007

Jordan S, Ruzsics Z, Mitrović M, Baranek T, Arapović J, Krmpotić A, i sur.. Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection. Cell Host & Microbe [Internet]. 05.2013. [pristupljeno 25.04.2024.];13(5):535-545. doi: 10.1016/j.chom.2013.04.007

S. Jordan, et al., "Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection", Cell Host & Microbe, vol. 13, br. 5, str. 535-545, Svibanj 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:563319. [Citirano: 25.04.2024.]

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Naslov (engleski)Natural Killer Cells Are Required for Extramedullary Hematopoiesis following Murine Cytomegalovirus Infection
AutorStefan Jordan
AutorZsolt Ruzsics
AutorMaja Mitrović
AutorThomas Baranek
AutorJurica Arapović
AutorAstrid Krmpotić
AutorEric Vivier
AutorMarc Dalod
AutorStipan Jonjić
AutorLars Dölken
AutorUlrich H. Koszinowski
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The immune response against a variety of pathogens can lead to activation of blood formation at ectopic sites, a process termed extramedullary hematopoiesis (EMH). The underlying mechanisms of EMH have been enigmatic. Investigating splenic EMH in mice infected with murine cytomegalovirus (MCMV), we find that, while cells of the adaptive immune system were dispensable for EMH, natural killer (NK) cells were essential. EMH required recognition of infected cells via activating NK cell receptors Ly49H or NKG2D, and correspondingly, viral interference with NK cell recognition abolished EMH. Surprisingly, development of EMH was not induced by NK cell-derived cytokines but was dependent on perforin-mediated cytotoxicity in order to control virus spread. Spreading virus reduced the numbers of F4/80(+) macrophages that were crucial for inflammatory EMH. Hence, whereas MCMV suppresses inflammation-induced EMH, NK cells confine virus spread, thereby protecting extramedullary hematopoietic niches and facilitating EMH.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCell Host & Microbe
Brojčani podacivol. 13, br. 5, str. 535-545
p-ISSN1931-3128
e-ISSN1934-6069
DOIhttps://doi.org/10.1016/j.chom.2013.04.007
URN:NBNurn:nbn:hr:184:563319
Datum objave publikacije2013-05
ProjektŠifra: 268537
Naziv (engleski): The Immune function of NK cells
Kratica: THINK
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S1931312813001492
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2018-10-17 19:15:38