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MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES I. Antibodies to Membrane Structures That Define the Cytolytic T Lymphocyte Subset in the Swine
Journal of Immunology, 133 (1984); 647-652. urn:nbn:hr:184:524920
Jonjić, Stipan; Koszinowski, Ulrich H.

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Jonjić, S. i Koszinowski, U. H. (1984). MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES I. Antibodies to Membrane Structures That Define the Cytolytic T Lymphocyte Subset in the Swine. Journal of Immunology, 133., 647-652. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:524920

Jonjić, Stipan i Ulrich H. Koszinowski. "MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES I. Antibodies to Membrane Structures That Define the Cytolytic T Lymphocyte Subset in the Swine." Journal of Immunology, vol. 133, 1984, str. 647-652. https://urn.nsk.hr/urn:nbn:hr:184:524920

Jonjić, Stipan i Ulrich H. Koszinowski. "MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES I. Antibodies to Membrane Structures That Define the Cytolytic T Lymphocyte Subset in the Swine." Journal of Immunology 133 (1984): 647-652. https://urn.nsk.hr/urn:nbn:hr:184:524920

Jonjić, S. i Koszinowski, U. H. (1984) 'MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES I. Antibodies to Membrane Structures That Define the Cytolytic T Lymphocyte Subset in the Swine', Journal of Immunology, 133, str. 647-652. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:524920 (Datum pristupa: 22.04.2024.)

Jonjić S, Koszinowski UH. MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES I. Antibodies to Membrane Structures That Define the Cytolytic T Lymphocyte Subset in the Swine. Journal of Immunology [Internet]. 1984. [pristupljeno 22.04.2024.];133:647-652. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:524920

S. Jonjić i U. H. Koszinowski, "MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES I. Antibodies to Membrane Structures That Define the Cytolytic T Lymphocyte Subset in the Swine", Journal of Immunology, vol. 133, str. 647-652, 1984. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:524920. [Citirano: 22.04.2024.]

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Naslov (engleski)MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES I. Antibodies to Membrane Structures That Define the Cytolytic T Lymphocyte Subset in the Swine
AutorStipan Jonjić
AutorUlrich H. Koszinowski
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
A panel of monoclonal antibodies (mAb) with specificity for swine leukocytes was prepared by somatic cell hybridization with the use of spleen cells from mice immunized with swine thymocytes. The reactivity of two mAb (295/33 and 122/28). which both immunoprecipitated from the surface of swine leukocytes an antigen termed 5-L2 with an apparent m.w. of 33 to 35 kilodaltons under reducing and 65 to 70 kilodaltons under nonreducing conditions. was investigated in detail. These mAb were reactive in indirect immunofluorescence with 50 to 60% of thymocytes. 35% of peripheral blood lymphocytes. and 55% of E rosette-positive cells; they were nonreactive with bone marrow cells. Ig+ B cells. nonrosetting lymphocytes. granulocytes. and monocytes. In functional studies. the elimination of 5-L2+ cells partially reduced the proliferative response to concanavalin A and pokeweed mitogen but not to Staphylococcus aureus and lipopolysaccharide. The 5-L2- subset proliferated well to alloantigens. Both cytolytic T effector cells and precursor cells carried the antigen 5-L2 and could be depleted from heterogeneous cell populations by both antibodies in the presence of complement. These data suggest that the mAb 295/33 and 122/28 recognize a specific polypeptide present on the surface of swine cytolytic T cells. These antibodies will be useful in studies on the swine immune system.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Immunology
Brojčani podacivol. 133, str. 647-652
p-ISSN0022-1767
e-ISSN1550-6606
URN:NBNurn:nbn:hr:184:524920
Datum objave publikacije1984
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-03-28 14:43:25