prikaz prve stranice dokumenta Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion
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Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion
eLife, 10 (2021); https://doi.org/10.7554/eLife.59350
Angulo, Guillem; Železnjak, Jelena; Martínez-Vicente, Pablo; Puñet-Ortiz, Joan; Hengel, Hartmut; Messerle, Martin; Oxenius, Annette; Jonjić, Stipan; Krmpotić, Astrid; Engel, Pablo; Angulo, Ana

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Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion | Rad u časopisu / Znanstveni rad - Izvorni znanstveni rad
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Angulo, G., Železnjak, J., Martínez Vicente, P., Puñet Ortiz, J., Hengel, H., Messerle, M. ... Angulo, A. (2021). Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion. eLife, 10.. doi: 10.7554/eLife.59350

Angulo, Guillem, et al. "Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion." eLife, vol. 10, 2021. https://doi.org/10.7554/eLife.59350

Angulo, Guillem, Jelena Železnjak, Pablo Martínez Vicente, Joan Puñet Ortiz, Hartmut Hengel, Martin Messerle, Annette Oxenius, et al. "Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion." eLife 10 (2021). https://doi.org/10.7554/eLife.59350

Angulo, G., et al. (2021) 'Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion', eLife, 10. doi: 10.7554/eLife.59350

Angulo G, Železnjak J, Martínez Vicente P, Puñet Ortiz J, Hengel H, Messerle M, i sur.. Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion. eLife [Internet]. 18.01.2021. [pristupljeno 13.04.2024.];10. doi: 10.7554/eLife.59350

G. Angulo, et al., "Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion", eLife, vol. 10, Siječanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:503816. [Citirano: 13.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:503816
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Naslov (engleski)Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion
AutorGuillem Angulo
AutorJelena Železnjak
AutorPablo Martínez-Vicente
AutorJoan Puñet-Ortiz
AutorHartmut Hengel
AutorMartin Messerle
AutorAnnette Oxenius
AutorStipan Jonjić
AutorAstrid Krmpotić
AutorPablo Engel
AutorAna Angulo
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Viral infections are controlled, and very often cleared, by activated T lymphocytes. The inducible co-stimulator (ICOS) mediates its functions by binding to its ligand ICOSL, enhancing T-cell activation and optimal germinal center (GC) formation. Here, we show that ICOSL is heavily downmodulated during infection of antigen presenting cells by different herpesviruses. We found that, in murine cytomegalovirus (MCMV), the immunoevasin m138/fcr-1 physically interacts with ICOSL, impeding its maturation and promoting its lysosomal degradation. This viral protein counteracts T-cell responses, in an ICOS-dependent manner, and limits virus control during the acute MCMV infection. Additionally, we report that blockade of ICOSL in MCMV-infected mice critically regulates the production of MCMV-specific antibodies due to a reduction of T follicular helper and GC B cells. Altogether, these findings reveal a novel mechanism evolved by MCMV to counteract adaptive immune surveillance and demonstrates a role of the ICOS:ICOSL axis in the host defense against herpesviruses.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objavePrihvaćen za objavljivanje
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaeLife
Brojčani podacivol. 10
e-ISSN2050-084X
DOIhttps://doi.org/10.7554/eLife.59350
URN:NBNurn:nbn:hr:184:503816
Datum objave publikacije2021-01-18
URL dokumentahttps://elifesciences.org/articles/59350
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2021-01-25 12:45:46