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Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo
Cell Reports, 19 (2017), 11; 2345-2356. https://doi.org/10.1016/j.celrep.2017.05.063
Hirche, Christoph; Frenz, Theresa; Haas, Simon F.; Döring, Marius; Borst, Katharina; Tegtmeyer, Pia-K.; Brizić, Ilija; Jordan, Stefan; Keyser, Kirsten; Chhatbar, Chintan; Pronk, Eline; Lin, Shuiping; Messerle, Martin; Jonjić, Stipan; Falk, Christine S.; Trumpp, Andreas; Essers, Marieke A.G.; Kalinke, Ulrich Više autora...

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Hirche, C., Frenz, T., Haas, S. F., Döring, M., Borst, K., Tegtmeyer, P. K. ... Kalinke, U. (2017). Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. Cell Reports, 19. (11), 2345-2356. doi: 10.1016/j.celrep.2017.05.063

Hirche, Christoph, et al. "Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo." Cell Reports, vol. 19, br. 11, 2017, str. 2345-2356. https://doi.org/10.1016/j.celrep.2017.05.063

Hirche, Christoph, Theresa Frenz, Simon F. Haas, Marius Döring, Katharina Borst, Pia K. Tegtmeyer, Ilija Brizić, et al. "Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo." Cell Reports 19, br. 11 (2017): 2345-2356. https://doi.org/10.1016/j.celrep.2017.05.063

Hirche, C., et al. (2017) 'Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo', Cell Reports, 19(11), str. 2345-2356. doi: 10.1016/j.celrep.2017.05.063

Hirche C, Frenz T, Haas SF, Döring M, Borst K, Tegtmeyer PK, i sur.. Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. Cell Reports [Internet]. 06.2017. [pristupljeno 05.05.2024.];19(11):2345-2356. doi: 10.1016/j.celrep.2017.05.063

C. Hirche, et al., "Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo", Cell Reports, vol. 19, br. 11, str. 2345-2356, Lipanj 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:463708. [Citirano: 05.05.2024.]

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Naslov (engleski)Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo
AutorChristoph Hirche
AutorTheresa Frenz
AutorSimon F. Haas
AutorMarius Döring
AutorKatharina Borst
AutorPia-K. Tegtmeyer
AutorIlija Brizić
AutorStefan Jordan
AutorKirsten Keyser
AutorChintan Chhatbar
AutorEline Pronk
AutorShuiping Lin
AutorMartin Messerle
AutorStipan Jonjić
AutorChristine S. Falk
AutorAndreas Trumpp
AutorMarieke A.G. Essers
AutorUlrich Kalinke
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Quiescent long-term hematopoietic stem cells (LT-HSCs) are efficiently activated by type I interferon (IFN-I). However, this effect remains poorly investigated in the context of IFN-I-inducing virus infections. Here we report that both vesicular stomatitis virus (VSV) and murine cytomegalovirus (MCMV) infection induce LT-HSC activation that substantially differs from the effects triggered upon injection of synthetic IFN-I-inducing agents. In both infections, inflammatory responses had to exceed local thresholds within the bone marrow to confer LT-HSC cell cycle entry, and IFN-I receptor triggering was not critical for this activation. After resolution of acute MCMV infection, LT-HSCs returned to phenotypic quiescence. However, non-acute MCMV infection induced a sustained inflammatory milieu within the bone marrow that was associated with long-lasting impairment of LT-HSC function. In conclusion, our results show that systemic virus infections fundamentally affect LT-HSCs and that also non-acute inflammatory stimuli in bone marrow donors can affect the reconstitution potential of bone marrow transplants.
Ključne riječi (hrvatski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCell Reports
Brojčani podacivol. 19, br. 11, str. 2345-2356
p-ISSN2211-1247
DOIhttps://doi.org/10.1016/j.celrep.2017.05.063
URN:NBNurn:nbn:hr:184:463708
Datum objave publikacije2017-06
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S2211124717307209
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-NC-SA 4.0)
Datum i vrijeme pohrane2020-04-18 17:30:20