prikaz prve stranice dokumenta Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review
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Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review
Croatian Medical Journal, 65 (2024), 3; 268-288. https://doi.org/10.3325/cmj.2024.65.268
Primorac, Dragan; Molnar, Vilim; Tsoukas, Dimitrios; Uzieliene, Ilona; Tremolada, Carlo; Brlek, Petar; Klarić, Emil; Vidović, Dinko; Zekušić, Marija; Pachaleva, Jolita; Bernotiene, Eiva; Wilson, Adrian; Mobasheri, Ali

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Primorac, D., Molnar, V., Tsoukas, D., Uzieliene, I., Tremolada, C., Brlek, P. ... Mobasheri, A. (2024). Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review. Croatian Medical Journal, 65. (3), 268-288. doi: 10.3325/cmj.2024.65.268

Primorac, Dragan, et al. "Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review." Croatian Medical Journal, vol. 65, br. 3, 2024, str. 268-288. https://doi.org/10.3325/cmj.2024.65.268

Primorac, Dragan, Vilim Molnar, Dimitrios Tsoukas, Ilona Uzieliene, Carlo Tremolada, Petar Brlek, Emil Klarić, et al. "Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review." Croatian Medical Journal 65, br. 3 (2024): 268-288. https://doi.org/10.3325/cmj.2024.65.268

Primorac, D., et al. (2024) 'Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review', Croatian Medical Journal, 65(3), str. 268-288. doi: 10.3325/cmj.2024.65.268

Primorac D, Molnar V, Tsoukas D, Uzieliene I, Tremolada C, Brlek P, i sur.. Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review. Croatian Medical Journal [Internet]. 26.05.2024. [pristupljeno 15.04.2025.];65(3):268-288. doi: 10.3325/cmj.2024.65.268

D. Primorac, et al., "Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review", Croatian Medical Journal, vol. 65, br. 3, str. 268-288, Svibanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:408509. [Citirano: 15.04.2025.]

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Naslov (engleski)Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review
AutorDragan Primorac
AutorVilim Molnar
AutorDimitrios Tsoukas
AutorIlona Uzieliene
AutorCarlo Tremolada
AutorPetar Brlek
AutorEmil Klarić
AutorDinko Vidović
AutorMarija Zekušić
AutorJolita Pachaleva
AutorEiva Bernotiene
AutorAdrian Wilson
AutorAli Mobasheri
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
This review evaluates the current landscape and future directions of regenerative medicine for knee cartilage repair, with a particular focus on tissue engineering strategies. In this context, scaffold-based approaches have emerged as promising solutions for cartilage regeneration. Synthetic scaffolds, while offering superior mechanical properties, often lack the biological cues necessary for effective tissue integration. Natural scaffolds, though biocompatible and biodegradable, frequently... Više suffer from inadequate mechanical strength. Hybrid scaffolds, combining elements of both synthetic and natural materials, present a balanced approach, enhancing both mechanical support and biological functionality. Advances in decellularized extracellular matrix scaffolds have shown potential in promoting cell infiltration and integration with native tissues. Additionally, bioprinting technologies have enabled the creation of complex, bioactive scaffolds that closely mimic the zonal organization of native cartilage, providing an optimal environment for cell growth and differentiation. The review also explores the potential of gene therapy and gene editing techniques, including CRISPR-Cas9, to enhance cartilage repair by targeting specific genetic pathways involved in tissue regeneration. The integration of these advanced therapies with tissue engineering approaches holds promise for developing personalized and durable treatments for knee cartilage injuries and osteoarthritis. In conclusion, this review underscores the importance of continued multidisciplinary collaboration to advance these innovative therapies from bench to bedside and improve outcomes for patients with knee cartilage damage. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 65, br. 3, str. 268-288
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2024.65.268
URN:NBNurn:nbn:hr:184:408509
Datum objave publikacije2024-05-26
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157252/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-NC-SA 4.0)
Datum i vrijeme pohrane2024-12-17 08:53:56
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