prikaz prve stranice dokumenta BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands
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BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands
Oncotarget, 8 (2017), 38; 643447-64357. https://doi.org/10.18632/oncotarget.17834
Mayes, Kimberly; Elsayed, Zeinab; Alhazmi, Aiman; Waters, Michael; Alkhatib, Suehyb G.; Roberts, Mark; Song, Carolyn; Peterson, Kristen; Chan, Vivian; Ailaney, Nikhil; Malapati, Pumoli; Blevins, Tana; Lisnić, Berislav; Dumur, Catherine I.; Landry, Joseph W. Više autora...

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Mayes, K., Elsayed, Z., Alhazmi, A., Waters, M., Alkhatib, S. G., Roberts, M. ... Landry, J. W. (2017). BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands. Oncotarget, 8. (38), 643447-64357. doi: 10.18632/oncotarget.17834

Mayes, Kimberly, et al. "BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands." Oncotarget, vol. 8, br. 38, 2017, str. 643447-64357. https://doi.org/10.18632/oncotarget.17834

Mayes, Kimberly, Zeinab Elsayed, Aiman Alhazmi, Michael Waters, Suehyb G. Alkhatib, Mark Roberts, Carolyn Song, et al. "BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands." Oncotarget 8, br. 38 (2017): 643447-64357. https://doi.org/10.18632/oncotarget.17834

Mayes, K., et al. (2017) 'BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands', Oncotarget, 8(38), str. 643447-64357. doi: 10.18632/oncotarget.17834

Mayes K, Elsayed Z, Alhazmi A, Waters M, Alkhatib SG, Roberts M, i sur.. BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands. Oncotarget [Internet]. 06.09.2017. [pristupljeno 25.04.2024.];8(38):643447-64357. doi: 10.18632/oncotarget.17834

K. Mayes, et al., "BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands", Oncotarget, vol. 8, br. 38, str. 643447-64357, Rujan 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:393775. [Citirano: 25.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:393775
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Podaci o radu
Naslov (engleski)BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands
AutorKimberly Mayes
AutorZeinab Elsayed
AutorAiman Alhazmi
AutorMichael Waters
AutorSuehyb G. Alkhatib
AutorMark Roberts
AutorCarolyn Song
AutorKristen Peterson
AutorVivian Chan
AutorNikhil Ailaney
AutorPumoli Malapati
AutorTana Blevins
AutorBerislav Lisnić
AutorCatherine I. Dumur
AutorJoseph W. Landry
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Using syngeneic BALB/c mouse breast cancer models, we show that the chromatin remodeling subunit bromodomain PHD finger transcription factor (BPTF) suppresses natural killer (NK) cell antitumor activity in the tumor microenvironment (TME). In culture, BPTF suppresses direct natural cytotoxicity receptor (NCR) mediated NK cell cytolytic activity to mouse and human cancer cell lines, demonstrating conserved functions. Blocking mouse NCR1 in vivo rescues BPTF KD tumor weights, demonstrating its importance for the control of tumor growth. We discovered that BPTF occupies heparanase (Hpse) regulatory elements, activating its expression. Increased heparanase activity results in reduced cell surface abundance of the NCR co-ligands: heparan sulfate proteoglycans (HSPGs). Using gain and loss of function approaches we show that elevated heparanase levels suppress NK cell cytolytic activity to tumor cells in culture. These results suggest that BPTF activates heparanase expression, which in turn reduces cell surface HSPGs and NCR co-ligands, inhibiting NK cell activity. Furthermore, gene expression data from human breast cancer tumors shows that elevated BPTF expression correlates with reduced antitumor immune cell signatures, supporting conserved roles for BPTF in suppressing antitumor immunity. Conditional BPTF depletion in established mouse breast tumors enhances antitumor immunity, suggesting that inhibiting BPTF could provide a novel immunotherapy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaOncotarget
Brojčani podacivol. 8, br. 38, str. 643447-64357
e-ISSN1949-2553
DOIhttps://doi.org/10.18632/oncotarget.17834
URN:NBNurn:nbn:hr:184:393775
Datum objave publikacije2017-09-06
Datum objave publikacije2017-09-08
URL dokumentahttp://www.oncotarget.com/fulltext/17834
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 3.0 (CC BY 3.0)
Datum i vrijeme pohrane2018-11-02 08:18:25