prikaz prve stranice dokumenta Combined prenatal exposure to mercury and LCPUFA on newborn's brain measures and neurodevelopment at the age of 18 months
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Combined prenatal exposure to mercury and LCPUFA on newborn's brain measures and neurodevelopment at the age of 18 months
Environmental Research, 178 (2019); 1-8. https://doi.org/10.1016/j.envres.2019.108682
Nišević, Jelena Radić; Prpić, Igor; Kolić, Ivana; Baždarić, Ksenija; Tratnik, Janja Snoj; Prpić, Ingrid Škarpa; Mazej, Darja; Špirić, Zdravko; Barbone, Fabio; Horvat, Milena

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Nišević, J. R., Prpić, I., Kolić, I., Baždarić, K., Tratnik, J. S., Prpić, I. Š. ... Horvat, M. (2019). Combined prenatal exposure to mercury and LCPUFA on newborn's brain measures and neurodevelopment at the age of 18 months. Environmental Research, 178., 1-8. doi: 10.1016/j.envres.2019.108682

Nišević, Jelena Radić, et al. "Combined prenatal exposure to mercury and LCPUFA on newborn's brain measures and neurodevelopment at the age of 18 months." Environmental Research, vol. 178, 2019, str. 1-8. https://doi.org/10.1016/j.envres.2019.108682

Nišević, Jelena Radić, Igor Prpić, Ivana Kolić, Ksenija Baždarić, Janja Snoj Tratnik, Ingrid Škarpa Prpić, Darja Mazej, Zdravko Špirić, Fabio Barbone i Milena Horvat. "Combined prenatal exposure to mercury and LCPUFA on newborn's brain measures and neurodevelopment at the age of 18 months." Environmental Research 178 (2019): 1-8. https://doi.org/10.1016/j.envres.2019.108682

Nišević, J. R., et al. (2019) 'Combined prenatal exposure to mercury and LCPUFA on newborn's brain measures and neurodevelopment at the age of 18 months', Environmental Research, 178, str. 1-8. doi: 10.1016/j.envres.2019.108682

Nišević JR, Prpić I, Kolić I, Baždarić K, Tratnik JS, Prpić IŠ, i sur.. Combined prenatal exposure to mercury and LCPUFA on newborn's brain measures and neurodevelopment at the age of 18 months. Environmental Research [Internet]. 2019. [pristupljeno 18.03.2025.];178:1-8. doi: 10.1016/j.envres.2019.108682

J. R. Nišević, et al., "Combined prenatal exposure to mercury and LCPUFA on newborn's brain measures and neurodevelopment at the age of 18 months", Environmental Research, vol. 178, str. 1-8, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:391434. [Citirano: 18.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:391434
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Podaci o radu
Naslov (engleski)Combined prenatal exposure to mercury and LCPUFA on newborn's brain measures and neurodevelopment at the age of 18 months
AutorJelena Radić Nišević
AutorIgor Prpić
AutorIvana Kolić
AutorKsenija Baždarić
AutorJanja Snoj Tratnik
AutorIngrid Škarpa Prpić
AutorDarja Mazej
AutorZdravko Špirić
MBZ: 162660
AutorFabio Barbone
AutorMilena Horvat
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku informatiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za pedijatriju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Objectives Prenatal exposure of long chain polyunsaturated fatty acids (LCPUFA) are essential for normal fetal growth and neurodevelopment. Availability of LCPUFA depends mostly on maternal fish consumption. Fish consumption also exposes the fetus to mercury which is well known neurotoxicant. We analyzed the associations of combined LCPUFA and mercury from fish consumption during pregnancy on newborn's brain measures and child neurodevelopment in a northern Adriatic coastal area. Patients and... Više methods The prospective cohort study included 257 mother – infant pairs enrolled in a susceptible population of the Public Health Impact on long- term, low-level, Mixed Element exposure (PHIME) EU Sixth Framework Programme from 2 recruitment areas of the northern part of the Adriatic coast. Umbilical cord blood taken at delivery was used for measuring concentration of total mercury (THg) and specific LCPUFA - docosahexaenoic acid (DHA) and arachidonic acid (ARA). Neonatal cranial sonography was performed at the age of 3 days in 57 newborns. Neurodevelopmental assessment of cognitive, motor and language skills were conducted at 257 children at the age of 18 months using the Bayley Scales of Infant and Toddler Development, Third Edition. The participants were divided into two groups depending on the THg concentration in the umbilical cord blood (exposed > 5.8 μg/L and unexposed < 5.8 μg/L). Dietary habits and exposures to environmental and social factors were assessed through questionnaires. Results There is a statistically significant difference in the cerebellum length (p = 0.032) and the superior frontal gyrus width (p = 0.023) between the exposed and the unexposed group. In combined analysis, including possible protective variables as DHA and ARA (R2 = 0.22, p = 0.001), the negative contribution of THg on cerebellum length (beta = −0.16, p = 0.001) persisted. We found no correlation between THg concentration in umbilical cord blood and child neurodevelopment scores at the age of 18 months. Language score with receptive and expressive subscores was significantly associated with fish consumption (p < 0.05). Conclusion This analysis demonstrates the existence of morphological brain changes in newborns that are prenatally exposed at mercury concentrations what was diminished in combined analyse including LCPUFA. Our results emphasizes the importance of LCPUFA's and mercury common influence as a predictor of developmental outcome. Fish consumption, not solely LCPUFA contributes to better language development of children at the age of 18 months. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEnvironmental Research
Brojčani podacivol. 178, str. 1-8
p-ISSN0013-9351
DOIhttps://doi.org/10.1016/j.envres.2019.108682
URN:NBNurn:nbn:hr:184:391434
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1047684
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-11 16:41:37
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