prikaz prve stranice dokumenta The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries
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The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries
Physiological Research, 69 (2020); 261-274. https://doi.org/10.33549/physiolres.934243
Saračević, Adrea; Medved, Igor; Hrabrić Vlah, Snježana; Kozmar, Ana; Bilić-Zulle, Lidija; Šimundić, Ana-Maria

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Saračević, A., Medved, I., Hrabrić Vlah, S., Kozmar, A., Bilić Zulle, L. i Šimundić, A. M.. The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries. Physiological Research, 69., 261-274. doi: 10.33549/physiolres.934243

Saračević, Adrea, et al. "The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries." Physiological Research, vol. 69, str. 261-274. https://doi.org/10.33549/physiolres.934243

Saračević, Adrea, Igor Medved, Snježana Hrabrić Vlah, Ana Kozmar, Lidija Bilić Zulle i Ana Maria Šimundić. "The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries." Physiological Research 69 261-274. https://doi.org/10.33549/physiolres.934243

Saračević, A., et al. 'The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries', Physiological Research, 69, str. 261-274. doi: 10.33549/physiolres.934243

Saračević A, Medved I, Hrabrić Vlah S, Kozmar A, Bilić Zulle L, Šimundić AM. The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries. Physiological Research [Internet]. [pristupljeno 06.05.2024.];69:261-274. doi: 10.33549/physiolres.934243

A. Saračević, I. Medved, S. Hrabrić Vlah, A. Kozmar, L. Bilić Zulle i A. M. Šimundić, "The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries", Physiological Research, vol. 69, str. 261-274. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:326197. [Citirano: 06.05.2024.]

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Podaci o radu
Naslov (engleski)The association of systemic inflammatory markers with indicators of stress and cardiac necrosis in patients undergoing aortic valve replacement and revascularization surgeries
AutorAdrea Saračević
AutorIgor Medved
AutorSnježana Hrabrić Vlah
AutorAna Kozmar
AutorLidija Bilić-Zulle
AutorAna-Maria Šimundić
Autorova ustanovaSveučilište u Zagrebu
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kliničko-laboratorijsku dijagnostiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
The aim was to investigate: changes of inflammatory, stress and cardiac response in patients undergoing open heart surgeries up to five days after the procedure; the association between inflammatory, stress and cardiac response and whether changes in a certain marker can predict short-term patient outcome. Ninety patients were divided into three groups, 30 participants each (on-pump,off-pump revascularization and valve replacement group). The following markers were measured:complete blood count, CRP, IL-6, IL-10, leptin, resistin, monocyte chemoattractant protein-1 (MCP-1), cortisol, CK and hsTnT in 5 points. Resistin increased in all three groups. Lower IL-10 levels were found after the surgery and higher levels of leptin and MCP-1 in the off pump than in the on-pump group. Off-pump group had higher values of IL-6, IL-10, leptin, resistin and MCP-1 and lower levels of CK and hsTnT 24 after surgery than the on-pump group. We found significant correlation between MCP-1 and resistin. The difference between resistin at time points 2 and 3 significantly predicted transfusion needs; while the difference between CRP and resistin before and at the end of the surgery together with the difference between leukocytes at the end and 24 hours after the surgery predicted the use of inotropic agents/vasopressors. Cardiac surgeries cause an increase of inflammatory, stress and cardiac markers. Only resistin correlated with MCP-1 which confirms the link between resistin secreted form infiltrated macrophages and enhanced release of MCP-1.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeNepoznato
Verzija publikacijeRukopis poslan na recenzijski postupak (preprint)
Naslov časopisaPhysiological Research
Brojčani podacivol. 69, str. 261-274
e-ISSN1802-9973
DOIhttps://doi.org/10.33549/physiolres.934243
URN:NBNurn:nbn:hr:184:326197
Datum prihvaćanja za tisak2020
URL dokumentahttps://doi.org/10.33549/physiolres.934243
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2020-03-31 15:47:26