prikaz prve stranice dokumenta Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes
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Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes
SAGE Open Medicine, 7 (2019); 1-8. https://doi.org/10.1177/2050312119865137
Dević Pavlić, Sanja; Tramišak Milaković, Tamara; Panić Horvat, Linda; Čavlović, Kristina; Vlašić, Hrvoje; Manestar, Miljenko; Smiljan Severinski, Neda; Radojčić Badovinac, Anđelka

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Dević Pavlić, S., Tramišak Milaković, T., Panić Horvat, L., Čavlović, K., Vlašić, H., Manestar, M. ... Radojčić Badovinac, A. (2019). Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes. SAGE Open Medicine, 7., 1-8. doi: 10.1177/2050312119865137

Dević Pavlić, Sanja, et al. "Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes." SAGE Open Medicine, vol. 7, 2019, str. 1-8. https://doi.org/10.1177/2050312119865137

Dević Pavlić, Sanja, Tamara Tramišak Milaković, Linda Panić Horvat, Kristina Čavlović, Hrvoje Vlašić, Miljenko Manestar, Neda Smiljan Severinski i Anđelka Radojčić Badovinac. "Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes." SAGE Open Medicine 7 (2019): 1-8. https://doi.org/10.1177/2050312119865137

Dević Pavlić, S., et al. (2019) 'Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes', SAGE Open Medicine, 7, str. 1-8. doi: 10.1177/2050312119865137

Dević Pavlić S, Tramišak Milaković T, Panić Horvat L, Čavlović K, Vlašić H, Manestar M, i sur.. Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes. SAGE Open Medicine [Internet]. 16.07.2019. [pristupljeno 05.05.2024.];7:1-8. doi: 10.1177/2050312119865137

S. Dević Pavlić, et al., "Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes", SAGE Open Medicine, vol. 7, str. 1-8, Srpanj 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:294760. [Citirano: 05.05.2024.]

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Naslov (engleski)Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes
AutorSanja Dević Pavlić
AutorTamara Tramišak Milaković
AutorLinda Panić Horvat
AutorKristina Čavlović
AutorHrvoje Vlašić
AutorMiljenko Manestar
AutorNeda Smiljan Severinski
AutorAnđelka Radojčić Badovinac
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Interdisciplinarne biotehničke znanosti
Sažetak (engleski)
Objectives: The aim of this study was to investigate the expression of genes crucial for the quality of the oocyte and whether expression levels of these genes in cumulus cells can be biological markers for the quality of the oocyte, zygote or embryo, or even for achievement of pregnancy after the assisted reproductive technology procedure. We examined the expression profile of the anti-Müllerian hormone (AMH) gene and its respective receptors: anti-Müllerian hormone receptor type 2 (AMHR2), follicle-stimulating hormone receptor (FSHR) and androgen receptor (AR) in cumulus cells (CCs) surrounding the oocyte, as well as AMH concentrations in follicular fluid of the associated follicle. The obtained gene expression levels were correlated with the morphological quality of the associated oocyte, zygote and embryo as well as with assisted reproductive technology outcome following the intracytoplasmic sperm injection procedure. Results: The results yielded suggest a relationship between AMH, AR and oocyte morphology: AMH and AR gene expression levels in CCs surrounding morphologically optimal oocytes were significantly lower than in CCs surrounding oocytes with suboptimal morphology (p = 0.011 and p = 0.008, respectively). Statistically significant positive correlation was found between mRNA expression levels of AMH and FSHR (p < 0.001), AMH and AR (p = 0.001), AMHR2 and FSHR (p < 0.001), AMHR2 and AR (p < 0.001), as well as between FSHR and AR (p < 0.001). Conclusion: Assessed results point to AMH and AR relation with oocyte maturity, but not with its fertilization potential, or with embryo quality.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaSAGE Open Medicine
Brojčani podacivol. 7, str. 1-8
e-ISSN2050-3121
DOIhttps://doi.org/10.1177/2050312119865137
URN:NBNurn:nbn:hr:184:294760
Datum objave publikacije2019-07-16
URL dokumentahttp://journals.sagepub.com/doi/10.1177/2050312119865137
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2019-10-11 09:26:55