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Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility
Immunity, 54 (2021); 1478-1493. https://doi.org/10.1016/j.immuni.2021.04.020
Tomac, Jelena; Mazor, Marija; Lisnić, Berislav; Golemac, Mijo; Kveštak, Daria; Bralić, Marina; Bilić-Zulle, Lidija; Brinkmann, Melanie M.; Dölken, Lars; Reinert, Line S.; Paludan, Soren R.; Krmpotić, Astrid; Jonjić, Stipan; Juranić Lisnić, Vanda

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Tomac, J., Mazor, M., Lisnić, B., Golemac, M., Kveštak, D., Bralić, M. ... Juranić Lisnić, V. (2021). Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. Immunity, 54., 1478-1493. doi: 10.1016/j.immuni.2021.04.020

Tomac, Jelena, et al. "Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility." Immunity, vol. 54, 2021, str. 1478-1493. https://doi.org/10.1016/j.immuni.2021.04.020

Tomac, Jelena, Marija Mazor, Berislav Lisnić, Mijo Golemac, Daria Kveštak, Marina Bralić, Lidija Bilić Zulle, et al. "Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility." Immunity 54 (2021): 1478-1493. https://doi.org/10.1016/j.immuni.2021.04.020

Tomac, J., et al. (2021) 'Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility', Immunity, 54, str. 1478-1493. doi: 10.1016/j.immuni.2021.04.020

Tomac J, Mazor M, Lisnić B, Golemac M, Kveštak D, Bralić M, i sur.. Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. Immunity [Internet]. 19.05.2021. [pristupljeno 14.04.2024.];54:1478-1493. doi: 10.1016/j.immuni.2021.04.020

J. Tomac, et al., "Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility", Immunity, vol. 54, str. 1478-1493, Svibanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:240644. [Citirano: 14.04.2024.]

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Naslov (engleski)Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility
AutorJelena Tomac
AutorMarija Mazor
AutorBerislav Lisnić
AutorMijo Golemac
AutorDaria Kveštak
AutorMarina Bralić
AutorLidija Bilić-Zulle
AutorMelanie M. Brinkmann
AutorLars Dölken
AutorLine S. Reinert
AutorSoren R. Paludan
AutorAstrid Krmpotić
AutorStipan Jonjić
AutorVanda Juranić Lisnić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Viral infections during pregnancy are a considerable cause of adverse outcomes and birth defects, and the underlying mechanisms are poorly understood. Among those, cytomegalovirus (CMV) infection stands out as the most common intrauterine infection in humans, putatively causing early pregnancy loss. We employed murine CMV as a model to study the consequences of viral infection on pregnancy outcome and fertility maintenance. Even though pregnant mice successfully controlled CMV infection, we observed highly selective, strong infection of corpus luteum (CL) cells in their ovaries. High infection densities indicated complete failure of immune control in CL cells, resulting in progesterone insufficiency and pregnancy loss. An abundance of gap junctions, absence of vasculature, strong type I interferon (IFN) responses, and interaction of innate immune cells fully protected the ovarian follicles from viral infection. Our work provides fundamental insights into the effect of CMV infection on pregnancy loss and mechanisms protecting fertility.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaImmunity
Brojčani podacivol. 54, str. 1478-1493
p-ISSN1074-7613
DOIhttps://doi.org/10.1016/j.immuni.2021.04.020
URN:NBNurn:nbn:hr:184:240644
Datum objave publikacije2021-05-19
ProjektŠifra: IP-2016-06-5980
Naziv (hrvatski): Patogeneza citomegalovirusne infekcije u jajnicima, utjecaj na plodnost i održavanje trudnoće
Naziv (engleski): Pathogenesis of cytomegalovirus infection in the ovaries, impact on fertility and pregnancy maintenance
Kratica: JaPI
Voditelj: Vanda Juranić Lisnić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: KK.011.1.01.0006
Naziv (engleski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: ERDF
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S1074761321001825
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2021-05-27 13:18:05