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Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection
The Journal of Experimental Medicine, 188 (1998), 6; 1047-1054. https://doi.org/10.1084/jem.188.6.1047
Polić, Bojan; Hengel, Hartmut; Krmpotić, Astrid; Trgovcich, Joanne; Pavić, Ivica; Lučin, Pero; Jonjić, Stipan; Koszinowski, Ulrich H.

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Polić, B., Hengel, H., Krmpotić, A., Trgovcich, J., Pavić, I., Lučin, P. ... Koszinowski, U. H. (1998). Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection. The Journal of Experimental Medicine, 188. (6), 1047-1054. doi: 10.1084/jem.188.6.1047

Polić, Bojan, et al. "Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection." The Journal of Experimental Medicine, vol. 188, br. 6, 1998, str. 1047-1054. https://doi.org/10.1084/jem.188.6.1047

Polić, Bojan, Hartmut Hengel, Astrid Krmpotić, Joanne Trgovcich, Ivica Pavić, Pero Lučin, Stipan Jonjić i Ulrich H. Koszinowski. "Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection." The Journal of Experimental Medicine 188, br. 6 (1998): 1047-1054. https://doi.org/10.1084/jem.188.6.1047

Polić, B., et al. (1998) 'Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection', The Journal of Experimental Medicine, 188(6), str. 1047-1054. doi: 10.1084/jem.188.6.1047

Polić B, Hengel H, Krmpotić A, Trgovcich J, Pavić I, Lučin P, i sur.. Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection. The Journal of Experimental Medicine [Internet]. 21.09.1998. [pristupljeno 14.04.2024.];188(6):1047-1054. doi: 10.1084/jem.188.6.1047

B. Polić, et al., "Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection", The Journal of Experimental Medicine, vol. 188, br. 6, str. 1047-1054, Rujan 1998. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:185952. [Citirano: 14.04.2024.]

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Podaci o radu
Naslov (engleski)Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection
AutorBojan Polić
AutorHartmut Hengel
AutorAstrid Krmpotić
AutorJoanne Trgovcich
AutorIvica Pavić
AutorPero Lučin
AutorStipan Jonjić
AutorUlrich H. Koszinowski
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Reactivation from latent cytomegalovirus (CMV) infection is often associated with conditions of immunosuppression and can result in fatal disease. Whether the maintenance of systemic CMV latency is mainly governed by factors of the infected cell or by immune control functions is unknown. Likewise, the putative immune control mechanisms which could prevent the induction and spread of recurrent CMV infection are not clearly identified. We took advantage of latently infected B cell-deficient mice and a sensitive method for virus detection to study CMV reactivation after ablation of lymphocyte subsets. A crucial role of both T lymphocytes and natural killer (NK) cells was demonstrated. Within 5 d after depletion of lymphocytes, productive infection occurred in 50% of mice, and 14 d later 100% of mice exhibited recurrent infection. A hierarchy of immune control functions of CD8(+), NK, and CD4(+) cells was established. Reactivation was rare if only one of the lymphocyte subsets was depleted, but was evident after removal of a further subset, indicating a functional redundancy of control mechanisms. The salivary glands were identified as the site of most rapid virus shedding, followed by the detection of recurrent virus in the lungs, and eventually in the spleen. Our findings document a previously unknown propensity of latent CMV genomes to enter productive infection immediately and with a high frequency after immune cell depletion. The data indicate that only the sustained cellular immune control prevents CMV replication and restricts the viral genome to a systemic state of latency.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaThe Journal of Experimental Medicine
Brojčani podacivol. 188, br. 6, str. 1047-1054
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.188.6.1047
URN:NBNurn:nbn:hr:184:185952
Datum objave publikacije1998-09-21
Datum objave publikacije1998-09-21
URL dokumentahttp://www.jem.org/lookup/doi/10.1084/jem.188.6.1047
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2018-12-12 18:15:10