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NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis
Immunity, 48 (2018), 1; 107-119. https://doi.org/10.1016/j.immuni.2017.12.007
Glasner, Ariella; Levi, Assi; ...; Jonjić, Stipan; ...; Mandelboim, Ofer

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Glasner, A., Levi, A., Jonjić, S. i Mandelboim, O. (2018). NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis. Immunity, 48. (1), 107-119. doi: 10.1016/j.immuni.2017.12.007

Glasner, Ariella, et al. "NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis." Immunity, vol. 48, br. 1, 2018, str. 107-119. https://doi.org/10.1016/j.immuni.2017.12.007

Glasner, Ariella, Assi Levi, Stipan Jonjić i Ofer Mandelboim. "NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis." Immunity 48, br. 1 (2018): 107-119. https://doi.org/10.1016/j.immuni.2017.12.007

Glasner, A., et al. (2018) 'NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis', Immunity, 48(1), str. 107-119. doi: 10.1016/j.immuni.2017.12.007

Glasner A, Levi A, Jonjić S, Mandelboim O. NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis. Immunity [Internet]. 16.01.2018. [pristupljeno 13.04.2024.];48(1):107-119. doi: 10.1016/j.immuni.2017.12.007

A. Glasner, A. Levi, S. Jonjić i O. Mandelboim, "NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis", Immunity, vol. 48, br. 1, str. 107-119, Siječanj 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:184731. [Citirano: 13.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:184731
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Naslov (engleski)NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis
AutorAriella Glasner
AutorAssi Levi
Autor
...
AutorStipan Jonjić
Autor
...
AutorOfer Mandelboim
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Natural killer (NK) cells are innate lymphoid cells, and their presence within human tumors correlates with better prognosis. However, the mechanisms by which NK cells control tumors in vivo are unclear. Here, we used reflectance confocal microscopy (RCM) imaging in humans and in mice to visualize tumor architecture in vivo.We demonstrated that signaling via the NK cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-g (IFN-g) secretion from intratumoral NK cells. NKp46- and Ncr1-mediated IFN-g production led to the increased expression of the extracellular matrix protein fibronectin 1 (FN1) in the tumors, which altered primary tumor architecture and resulted in decreased metastases formation. Injection of IFN-g into tumor-bearing mice or transgenic overexpression of Ncr1 in NK cells in mice resulted in decreased metastasis formation. Thus, we have defined a mechanism of NK cell-mediated control of metastases in vivo that may help develop NK cell-dependent cancer therapies.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaImmunity
Brojčani podacivol. 48, br. 1, str. 107-119
p-ISSN1074-7613
e-ISSN1097-4180
DOIhttps://doi.org/10.1016/j.immuni.2017.12.007
URN:NBNurn:nbn:hr:184:184731
Datum objave publikacije2018-01-16
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 721317
Naziv (engleski): TIGIT therapy for cancer treatment
Kratica: TIGITtherapy
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: H2020
URL dokumentahttps://doi.org/10.1016/j.immuni.2017.12.007
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-02-11 14:28:04