prikaz prve stranice dokumenta Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.
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Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.
PLoS Pathogens, 12 (2016), 12; :e1006015. https://doi.org/10.1371/journal.ppat.1006015.
Tomić, Adriana; Varanasi, Pavankumar R.; Golemac, Mijo; Malić, Suzana; Riese, Peggy; Mischak-Weissinger, Eva; Guzman, CA; Krmpotić, Astrid; Jonjić, Stipan; Messerle, Martin

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Tomić, A., Varanasi, P. R., Golemac, M., Malić, S., Riese, P., Mischak Weissinger, E. ... Messerle, M. (2016). Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.. PLoS Pathogens, 12. (12). doi: 10.1371/journal.ppat.1006015.

Tomić, Adriana, et al. "Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.." PLoS Pathogens, vol. 12, br. 12, 2016. https://doi.org/10.1371/journal.ppat.1006015.

Tomić, Adriana, Pavankumar R. Varanasi, Mijo Golemac, Suzana Malić, Peggy Riese, Eva Mischak Weissinger, CA Guzman, Astrid Krmpotić, Stipan Jonjić i Martin Messerle. "Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.." PLoS Pathogens 12, br. 12 (2016). https://doi.org/10.1371/journal.ppat.1006015.

Tomić, A., et al. (2016) 'Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.', PLoS Pathogens, 12(12). doi: 10.1371/journal.ppat.1006015.

Tomić A, Varanasi PR, Golemac M, Malić S, Riese P, Mischak Weissinger E, i sur.. Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.. PLoS Pathogens [Internet]. 2016. [pristupljeno 16.04.2024.];12(12). doi: 10.1371/journal.ppat.1006015.

A. Tomić, et al., "Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.", PLoS Pathogens, vol. 12, br. 12, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:183434. [Citirano: 16.04.2024.]

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Naslov (engleski)Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.
AutorAdriana Tomić
AutorPavankumar R. Varanasi
AutorMijo Golemac
AutorSuzana Malić
AutorPeggy Riese
AutorEva Mischak-Weissinger
AutorCA Guzman
AutorAstrid Krmpotić
AutorStipan Jonjić
AutorMartin Messerle
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Development of an effective vaccine against human cytomegalovirus (HCMV) is a need of utmost medical importance. Generally, it is believed that a live attenuated vaccine would best provide protective immunity against this tenacious pathogen. Here, we propose a strategy for an HCMV vaccine that aims at the simultaneous activation of innate and adaptive immune responses. An HCMV strain expressing the host ligand ULBP2 for the NKG2D receptor was found to be susceptible to control by natural killer (NK) cells, and preserved the ability to stimulate HCMV-specific T cells. Infection with the ULBP2-expressing HCMV strain caused diminished cell surface levels of MHC class I molecules. While expression of the NKG2D ligand increased the cytolytic activity of NK cells, NKG2D engagement in CD8+ T cells provided co-stimulation and compensated for lower MHC class I expression. Altogether, our data indicate that triggering of both arms of the immune system is a promising approach applicable to the generation of a live attenuated HCMV vaccine.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS Pathogens
Brojčani podacivol. 12, br. 12, :e1006015
p-ISSN1553-7366
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1006015.
URN:NBNurn:nbn:hr:184:183434
Datum objave publikacije2016
ProjektŠifra: 322693
Naziv (engleski): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Kratica: STADVINN
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
URL dokumentaournals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006015
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-06-23 13:15:00