prikaz prve stranice dokumenta Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections
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Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections
Pathogens, 10 (2021), 8; 1062. https://doi.org/10.3390/pathogens10081062
Moulden, Jerome; Sung, Cathy Yea Won; Brizić, Ilija; Jonjić, Stipan; Britt, William J.

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Moulden, J., Sung, C. Y. W., Brizić, I., Jonjić, S. i Britt, W. J. (2021). Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections. Pathogens, 10. (8). doi: 10.3390/pathogens10081062

Moulden, Jerome, et al. "Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections." Pathogens, vol. 10, br. 8, 2021. https://doi.org/10.3390/pathogens10081062

Moulden, Jerome, Cathy Yea Won Sung, Ilija Brizić, Stipan Jonjić i William J. Britt. "Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections." Pathogens 10, br. 8 (2021). https://doi.org/10.3390/pathogens10081062

Moulden, J., et al. (2021) 'Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections', Pathogens, 10(8). doi: 10.3390/pathogens10081062

Moulden J, Sung CYW, Brizić I, Jonjić S, Britt WJ. Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections. Pathogens [Internet]. 21.08.2021. [pristupljeno 26.04.2024.];10(8). doi: 10.3390/pathogens10081062

J. Moulden, C. Y. W. Sung, I. Brizić, S. Jonjić i W. J. Britt, "Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections", Pathogens, vol. 10, br. 8, Kolovoz 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:156194. [Citirano: 26.04.2024.]

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Naslov (engleski)Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections
AutorJerome Moulden
AutorCathy Yea Won Sung
AutorIlija Brizić
AutorStipan Jonjić
AutorWilliam J. Britt
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Human cytomegalovirus infection of the developing fetus is a leading cause of neurodevelopmental disorders in infants and children, leading to long-term neurological sequela in a significant number of infected children. Current understanding of the neuropathogenesis of this intrauterine infection is limited because of the complexity of this infection, which includes maternal immunological responses that are overlaid on virus replication in the CNS during neurodevelopment. Furthermore, available data from human cases are observational, and tissues from autopsy studies have been derived from only the most severe infections. Animal models of this human infection are also limited by the strict species specificity of cytomegaloviruses. However, informative models including non-human primates and small animal models have been developed. These include several different murine models of congenital HCMV infection for the study of CMV neuropathogenesis. Although individual murine models do not completely recapitulate all aspects of the human infection, each model has provided significant information that has extended current understanding of the neuropathogenesis of this human infection. This review will compare and contrast different murine models in the context of available information from human studies of CNS disease following congenital HCMV infections.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPathogens
Brojčani podacivol. 10, br. 8, 1062
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens10081062
URN:NBNurn:nbn:hr:184:156194
Datum objave publikacije2021-08-21
ProjektŠifra: KK.01.1.1.01.0006
Naziv (engleski): Strengthening the capacity of CerVirVac for research in virus immunology and vaccinology
Voditelj: Stipan Jonjić
Pravna nadležnost: eu
Financijer: European Regional Development Fund
URL dokumentahttps://www.mdpi.com/2076-0817/10/8/1062
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-09-17 12:45:49