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Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model
Viruses, 16 (2024), 2; 208. https://doi.org/10.3390/v16020208
Karner, Dubravka; Kveštak, Daria; Lisnić, Berislav; Cokaric Brdovčak, Maja; Juranić Lisnić, Vanda; Kučan Brlić, Paola; Hasan, Milena; Lenac Roviš, Tihana

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Karner, D., Kveštak, D., Lisnić, B., Cokaric Brdovčak, M., Juranić Lisnić, V., Kučan Brlić, P. ... Lenac Roviš, T. (2024). Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model. Viruses, 16. (2). doi: 10.3390/v16020208

Karner, Dubravka, et al. "Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model." Viruses, vol. 16, br. 2, 2024. https://doi.org/10.3390/v16020208

Karner, Dubravka, Daria Kveštak, Berislav Lisnić, Maja Cokaric Brdovčak, Vanda Juranić Lisnić, Paola Kučan Brlić, Milena Hasan i Tihana Lenac Roviš. "Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model." Viruses 16, br. 2 (2024). https://doi.org/10.3390/v16020208

Karner, D., et al. (2024) 'Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model', Viruses, 16(2). doi: 10.3390/v16020208

Karner D, Kveštak D, Lisnić B, Cokaric Brdovčak M, Juranić Lisnić V, Kučan Brlić P, i sur.. Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model. Viruses [Internet]. 30.01.2024. [pristupljeno 08.04.2025.];16(2). doi: 10.3390/v16020208

D. Karner, et al., "Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model", Viruses, vol. 16, br. 2, Siječanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:123928. [Citirano: 08.04.2025.]

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Naslov (engleski)Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model
AutorDubravka Karner
AutorDaria Kveštak
AutorBerislav Lisnić
AutorMaja Cokaric Brdovčak
AutorVanda Juranić Lisnić
AutorPaola Kučan Brlić
AutorMilena Hasan
AutorTihana Lenac Roviš
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Congenital human cytomegalovirus (HCMV) infection may cause life-threatening disease and permanent damage to the central nervous system. The mouse model of CMV infection is most commonly used to study mechanisms of infection and pathogenesis. While essential to limit mouse CMV (MCMV) replication, the inflammatory responses, particularly IFNγ and TNFα, cause neurodevelopmental abnormalities. Other soluble mediators of the immune response in most tissues remain largely unexplored. To address this... Više gap, we quantified 48 soluble mediators of the immune response, including 32 cytokines, 10 chemokines, 3 growth factors/regulators, and 3 soluble receptors in the spleen, liver, lungs, and brain at 9 and 14 days postinfection (dpi). Our analysis found 25 induced molecules in the brain at 9 dpi, with an additional 8 showing statistically elevated responses at 14 dpi. Specifically, all analyzed CCL group cytokines (CCL2, CCL3, CCL4, CCL5, CCL7, and CCL11) were upregulated at 14 dpi in the brain. Furthermore, data revealed differentially regulated analytes across tissues, such as CCL11, CXCL5, and IL-10 in the brain, IL-33/IL-33R in the liver, and VEGF-a and IL-5 in the lungs. Overall, this study provides an overview of the immune dynamics of soluble mediators in congenital CMV. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaViruses
Brojčani podacivol. 16, br. 2, 208
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v16020208
URN:NBNurn:nbn:hr:184:123928
Datum objave publikacije2024-01-30
ProjektŠifra: IP-2020-02-6617
Naziv (hrvatski): Imunoregulatorna uloga proteina PrPC u imunološkom antivirusnom odgovoru i otpornosti na citomegalovirusnu infekciju
Kratica: PrImReg
Voditelj: Tihana Lenac Roviš
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: uniri-biomed-18-233
Naziv (hrvatski): Međuodnos proteina PrPc i imunološkog sustava tijekom virusne infekcije
Naziv (engleski): The role of PrPC in the immune system upon exposure to viruses
Voditelj: Tihana Lenac Roviš
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Nema
URL dokumentahttps://www.mdpi.com/1999-4915/16/2/208
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-02-05 14:12:29
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