prikaz prve stranice dokumenta Can pain intensity in osteoarthritis joint be indicator of the impairment of endothelial function?
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Can pain intensity in osteoarthritis joint be indicator of the impairment of endothelial function?
Medical hypotheses, 94 (2016); 15-19. https://doi.org/10.1016/j.mehy.2016.06.001
Laškarin, Gordana; Peršić, Viktor; Rusac Kukić, Sandra; Massari, Dražen; Legović, Anita; Boban, Marko; Miškulin, Rajko; Rogoznica, Marija; Kehler, Tatjana

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Laškarin, G., Peršić, V., Rusac Kukić, S., Massari, D., Legović, A., Boban, M. ... Kehler, T. (2016). Can pain intensity in osteoarthritis joint be indicator of the impairment of endothelial function?. Medical hypotheses, 94., 15-19. doi: 10.1016/j.mehy.2016.06.001

Laškarin, Gordana, et al. "Can pain intensity in osteoarthritis joint be indicator of the impairment of endothelial function?." Medical hypotheses, vol. 94, 2016, str. 15-19. https://doi.org/10.1016/j.mehy.2016.06.001

Laškarin, Gordana, Viktor Peršić, Sandra Rusac Kukić, Dražen Massari, Anita Legović, Marko Boban, Rajko Miškulin, Marija Rogoznica i Tatjana Kehler. "Can pain intensity in osteoarthritis joint be indicator of the impairment of endothelial function?." Medical hypotheses 94 (2016): 15-19. https://doi.org/10.1016/j.mehy.2016.06.001

Laškarin, G., et al. (2016) 'Can pain intensity in osteoarthritis joint be indicator of the impairment of endothelial function?', Medical hypotheses, 94, str. 15-19. doi: 10.1016/j.mehy.2016.06.001

Laškarin G, Peršić V, Rusac Kukić S, Massari D, Legović A, Boban M, i sur.. Can pain intensity in osteoarthritis joint be indicator of the impairment of endothelial function?. Medical hypotheses [Internet]. 2016. [pristupljeno 10.04.2025.];94:15-19. doi: 10.1016/j.mehy.2016.06.001

G. Laškarin, et al., "Can pain intensity in osteoarthritis joint be indicator of the impairment of endothelial function?", Medical hypotheses, vol. 94, str. 15-19, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:117060. [Citirano: 10.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:117060
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Naslov (engleski)Can pain intensity in osteoarthritis joint be indicator of the impairment of endothelial function?
AutorGordana Laškarin
AutorViktor Peršić
AutorSandra Rusac Kukić
AutorDražen Massari
AutorAnita Legović
AutorMarko Boban
MBZ: 340711
AutorRajko Miškulin
AutorMarija Rogoznica
AutorTatjana Kehler
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ortopediju i fizikalnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
We propose that pathological remodeling in joint tissues of osteoarthritis (OA) patients persistently stimulates local secretion of pro-inflammatory mediators, which overflow into the blood, activating leukocytes that impair endothelial function and accelerate the atherosclerotic process. During periods of pain, endothelial dysfunction progresses more aggressively due to elevated secretion of these pro-inflammatory mediators, which are involved in both atherosclerosis and the sensation of pain.... Više Concentrations of pro-inflammatory cytokines and their antagonists, activating and decoy receptors of the broad interleukin (IL)-1 and IL-17 families, IL-15, and monocyte chemotactic protein-1 should be measured in peripheral blood samples of OA patients and compared with (I) OA clinical severity ; (II) subclinical parameters of atherosclerosis ; (III) ischemic heart disease risk factors ; (IV) soluble factors indicating endothelial dysfunction ; (V) degree of bone destruction ; and (VI) results of a six-minute walk test. Arthroscopy and joint replacement surgery provide an opportunity to estimate mRNA and protein expression of inflammatory mediators in specimens of synovial fluid, synovial membrane, cartilage, and/or subarticular bone. A range of methods, including questionnaires, X-ray, computed tomography, ultrasound, enzyme-linked immunosorbent assay, immunohistology, immunofluorescence, and reverse transcription and in situ polymerase chain reaction are available. Understanding the inflammatory and immune mechanisms underlying OA may allow the early identification of patients at high risk of cardiovascular disease, independently of classical coronary risk factors. Pain may constitute an extrinsic indicator of currently worsening endothelial function Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical hypotheses
Brojčani podacivol. 94, str. 15-19
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2016.06.001
URN:NBNurn:nbn:hr:184:117060
Datum objave publikacije2016
URL dokumentahttp://bib.irb.hr/850570
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-08 18:25:16
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