prikaz prve stranice dokumenta Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection
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Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection
Frontiers in Microbiology, 10 (2019); 185. https://doi.org/10.3389/fmicb.2019.00185
Stojanović, Bojana; Milovanović, Jelena; Arsenijević, Aleksandar; Stojanović, Bojan; Stražić Geljić, Ivana; Arsenijević, Nebojša; Jonjić, Stipan; Lukić, Miodrag L.; Milovanović, Marija

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Stojanović, B., Milovanović, J., Arsenijević, A., Stojanović, B., Stražić Geljić, I., Arsenijević, N. ... Milovanović, M. (2019). Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection. Frontiers in Microbiology, 10.. doi: 10.3389/fmicb.2019.00185

Stojanović, Bojana, et al. "Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection." Frontiers in Microbiology, vol. 10, 2019. https://doi.org/10.3389/fmicb.2019.00185

Stojanović, Bojana, Jelena Milovanović, Aleksandar Arsenijević, Bojan Stojanović, Ivana Stražić Geljić, Nebojša Arsenijević, Stipan Jonjić, Miodrag L. Lukić i Marija Milovanović. "Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection." Frontiers in Microbiology 10 (2019). https://doi.org/10.3389/fmicb.2019.00185

Stojanović, B., et al. (2019) 'Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection', Frontiers in Microbiology, 10. doi: 10.3389/fmicb.2019.00185

Stojanović B, Milovanović J, Arsenijević A, Stojanović B, Stražić Geljić I, Arsenijević N, i sur.. Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection. Frontiers in Microbiology [Internet]. 08.02.2019. [pristupljeno 16.04.2024.];10. doi: 10.3389/fmicb.2019.00185

B. Stojanović, et al., "Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection", Frontiers in Microbiology, vol. 10, Veljača 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:088987. [Citirano: 16.04.2024.]

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Naslov (engleski)Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection
AutorBojana Stojanović
AutorJelena Milovanović
AutorAleksandar Arsenijević
AutorBojan Stojanović
AutorIvana Stražić Geljić
AutorNebojša Arsenijević
AutorStipan Jonjić
AutorMiodrag L. Lukić
AutorMarija Milovanović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Galectin-3 (Gal-3) has a role in multiple inflammatory pathways. Various, opposite roles of Gal-3 in liver diseases have been described but there are no data about the role of Gal-3 in development of hepatitis induced with cytomegalovirus infection. In this study we aimed to clarify the role of Gal-3 in murine cytomegalovirus (MCMV)-induced hepatitis by using Gal-3-deficient (Gal-3 KO) mice. Here we provide the evidence that Gal-3 has the protective role in MCMV-induced hepatitis. Enhanced hepatitis manifested by more inflammatory and necrotic foci and serum level of ALT, enhanced apoptosis and necroptosis of hepatocytes and enhanced viral replication were detected in MCMV-infected Gal-3 deficient mice. NK cells does not contribute to more severe liver damage in MCMV-infected Gal-3 KO mice. Enhanced expression of TNF-α in the hepatocytes of Gal-3 KO mice after MCMV infection, abrogated hepatocyte death, and attenuated inflammation in the livers of Gal-3 KO mice after TNF-α blockade suggest that TNF-α plays the role in enhanced disease in Gal-3 deficient animals. Treatment with recombinant Gal-3 reduces inflammation and especially necrosis of hepatocytes in the livers of MCMV-infected Gal-3 KO mice. Our data highlight the protective role of Gal-3 in MCMV-induced hepatitis by attenuation of TNF-α-mediated death of hepatocytes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Microbiology
Brojčani podacivol. 10, 185
e-ISSN1664-302X
DOIhttps://doi.org/10.3389/fmicb.2019.00185
URN:NBNurn:nbn:hr:184:088987
Datum objave publikacije2019-02-08
URL dokumentahttps://www.frontiersin.org/article/10.3389/fmicb.2019.00185/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 3.0 (CC BY 3.0)
Datum i vrijeme pohrane2019-03-05 14:28:04