prikaz prve stranice dokumenta Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals
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Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals
Journal of clinical medicine, 9 (2020), 3; 843-852. https://doi.org/10.3390/jcm9030843
Barić, Lidija; Drenjančević, Ines; Mihalj, Martina; Matić, Anita; Stupin, Marko; Kolar, Luka; Mihaljević, Zrinka; Mrakovčić-Šutić, Ines; Šerić, Vatroslav; Stupin, Ana

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Barić, L., Drenjančević, I., Mihalj, M., Matić, A., Stupin, M., Kolar, L. ... Stupin, A. (2020). Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals. Journal of clinical medicine, 9. (3), 843-852. doi: 10.3390/jcm9030843

Barić, Lidija, et al. "Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals." Journal of clinical medicine, vol. 9, br. 3, 2020, str. 843-852. https://doi.org/10.3390/jcm9030843

Barić, Lidija, Ines Drenjančević, Martina Mihalj, Anita Matić, Marko Stupin, Luka Kolar, Zrinka Mihaljević, Ines Mrakovčić Šutić, Vatroslav Šerić i Ana Stupin. "Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals." Journal of clinical medicine 9, br. 3 (2020): 843-852. https://doi.org/10.3390/jcm9030843

Barić, L., et al. (2020) 'Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals', Journal of clinical medicine, 9(3), str. 843-852. doi: 10.3390/jcm9030843

Barić L, Drenjančević I, Mihalj M, Matić A, Stupin M, Kolar L, i sur.. Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals. Journal of clinical medicine [Internet]. 2020. [pristupljeno 20.04.2024.];9(3):843-852. doi: 10.3390/jcm9030843

L. Barić, et al., "Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals", Journal of clinical medicine, vol. 9, br. 3, str. 843-852, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:085058. [Citirano: 20.04.2024.]

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Naslov (engleski)Enhanced antioxidative defense by vitamins C and E consumption prevents 7-day high-salt diet-induced microvascular endothelial function impairment in young healthy individuals
AutorLidija Barić
AutorInes Drenjančević
MBZ: 209603
AutorMartina Mihalj
MBZ: 322792
AutorAnita Matić
MBZ: 326344
AutorMarko Stupin
MBZ: 367386
AutorLuka Kolar
AutorZrinka Mihaljević
MBZ: 324952
AutorInes Mrakovčić-Šutić
AutorVatroslav Šerić
MBZ: 193563
AutorAna Stupin
MBZ: 322935
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
This study aimed to examine whether the oral supplementation of vitamins C and E during 7- days high salt diet (HS ; ~14 g salt/day) prevents microvascular endothelial function impairment and changes oxidative status caused by HS diet in 51 (26 women and 25 men) young healthy individuals. Laser Doppler flowmetry measurements demonstrated that skin post- occlusive reactive hyperemia (PORH), and acetylcholine-induced dilation (AChID) were significantly impaired in HS group, but not in HS+C+E group, while sodium nitroprusside- induced dilation remained unaffected by treatments. Serum oxidative stress markers: TBARS, 8-iso prostaglandin-F2α and leukocytes’ intracellular H2O2 production were significantly increased, while ferric-reducing ability of plasma (FRAP) and catalase concentrations were decreased in HS group. All these parameters remained unaffected by vitamins supplementation. Matrix metalloproteinase 9, antioxidant enzymes Cu/Zn SOD and glutathione peroxidase 1, and leukocytes’ intracellular superoxide production remained unchanged after the protocols in both HS and HS+C+E groups. Importantly, multiple regression analysis revealed that FRAP was the most powerful predictor of AChID, while PORH was strongly predicted by both FRAP and renin- angiotensin system activity. Hereby, we demonstrated that oxidative dis-balance has the pivotal role in HS diet-induced impairment of endothelial and microvascular function in healthy individuals which could be prevented by antioxidative vitamins consumption.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of clinical medicine
Brojčani podacivol. 9, br. 3, str. 843-852
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm9030843
URN:NBNurn:nbn:hr:184:085058
Datum objave publikacije2020
ProjektŠifra: IP-2016-06-8744
Naziv (hrvatski): Interakcija renin-angiotenzinskog i adrenergičkog sustava u aktivaciji endotela uzrokovanoj oksidativnim stresom
Kratica: RAS-AdrenOX
Voditelj: Ana Stupin rođ. Čavka
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttp://bib.irb.hr/1054795
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-03-31 14:47:04