prikaz prve stranice dokumenta The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
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The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
Proceedings of the National Academy of Sciences, 106 (2009), 42; 17858-17863. https://doi.org/10.1073/pnas.0903474106
Stanietsky, N.; Šimic, Hrvoje; Arapović, Jurica; Toporik, A.; Levy, O.; Novik, A.; Levine, Z.; Beiman, M.; Dassa, L.; Achdout, H.; Stern-Ginossar, N.; Tsukerman, P.; Jonjić, Stipan; Mandelboim, O.

Citirajte ovaj rad

Stanietsky, N., Šimic, H., Arapović, J., Toporik, A., Levy, O., Novik, A. ... Mandelboim, O. (2009). The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proceedings of the National Academy of Sciences, 106. (42), 17858-17863. doi: 10.1073/pnas.0903474106

Stanietsky, N., et al. "The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity." Proceedings of the National Academy of Sciences, vol. 106, br. 42, 2009, str. 17858-17863. https://doi.org/10.1073/pnas.0903474106

Stanietsky, N., Hrvoje Šimic, Jurica Arapović, A. Toporik, O. Levy, A. Novik, Z. Levine, et al. "The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity." Proceedings of the National Academy of Sciences 106, br. 42 (2009): 17858-17863. https://doi.org/10.1073/pnas.0903474106

Stanietsky, N., et al. (2009) 'The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity', Proceedings of the National Academy of Sciences, 106(42), str. 17858-17863. doi: 10.1073/pnas.0903474106

Stanietsky N, Šimic H, Arapović J, Toporik A, Levy O, Novik A, i sur.. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proceedings of the National Academy of Sciences [Internet]. 07.10.2009. [pristupljeno 23.04.2024.];106(42):17858-17863. doi: 10.1073/pnas.0903474106

N. Stanietsky, et al., "The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity", Proceedings of the National Academy of Sciences, vol. 106, br. 42, str. 17858-17863, Listopad 2009. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:064979. [Citirano: 23.04.2024.]

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Naslov (engleski)The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
AutorN. Stanietsky
AutorHrvoje Šimic
AutorJurica Arapović
AutorA. Toporik
AutorO. Levy
AutorA. Novik
AutorZ. Levine
AutorM. Beiman
AutorL. Dassa
AutorH. Achdout
AutorN. Stern-Ginossar
AutorP. Tsukerman
AutorStipan Jonjić
AutorO. Mandelboim
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of the inhibitory receptors bind MHC class I proteins and are expressed in a variegated fashion. It was recently shown that TIGIT, a new protein expressed by T and NK cells binds to PVR and PVR-like receptors and inhibits T cell activity indirectly through the manipulation of DC activity. Here, we show that TIGIT is expressed by all human NK cells, that it binds PVR and PVRL2 but not PVRL3 and that it inhibits NK cytotoxicity directly through its ITIM. Finally, we show that TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytoxicity thus providing an “alternative self” mechanism for MHC class I inhibition.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaProceedings of the National Academy of Sciences
Brojčani podacivol. 106, br. 42, str. 17858-17863
p-ISSN0027-8424
e-ISSN1091-6490
DOIhttps://doi.org/10.1073/pnas.0903474106
URN:NBNurn:nbn:hr:184:064979
Datum objave publikacije2009-10-07
Datum objave publikacije2009-10-20
URL dokumentahttp://www.pnas.org/cgi/doi/10.1073/pnas.0903474106
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-08 22:42:17