prikaz prve stranice dokumenta Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
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Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
BBA - Biochimica et Biophysica Acta, 1842 (2014); 817-830. https://doi.org/10.1016/j.bbadis.2013.08.014
Bursać, Slađana; Cokarić Brdovčak, Maja; Donati, Giulio; Volarević, Siniša

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Bursać, S., Cokarić Brdovčak, M., Donati, G. i Volarević, S. (2014). Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis. BBA - Biochimica et Biophysica Acta, 1842., 817-830. doi: 10.1016/j.bbadis.2013.08.014

Bursać, Slađana, et al. "Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis." BBA - Biochimica et Biophysica Acta, vol. 1842, 2014, str. 817-830. https://doi.org/10.1016/j.bbadis.2013.08.014

Bursać, Slađana, Maja Cokarić Brdovčak, Giulio Donati i Siniša Volarević. "Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis." BBA - Biochimica et Biophysica Acta 1842 (2014): 817-830. https://doi.org/10.1016/j.bbadis.2013.08.014

Bursać, S., et al. (2014) 'Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis', BBA - Biochimica et Biophysica Acta, 1842, str. 817-830. doi: 10.1016/j.bbadis.2013.08.014

Bursać S, Cokarić Brdovčak M, Donati G, Volarević S. Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis. BBA - Biochimica et Biophysica Acta [Internet]. 2014. [pristupljeno 17.04.2024.];1842:817-830. doi: 10.1016/j.bbadis.2013.08.014

S. Bursać, M. Cokarić Brdovčak, G. Donati i S. Volarević, "Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis", BBA - Biochimica et Biophysica Acta, vol. 1842, str. 817-830, 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:017875. [Citirano: 17.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:017875
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Naslov (engleski)Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
AutorSlađana Bursać
AutorMaja Cokarić Brdovčak
AutorGiulio Donati
AutorSiniša Volarević
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za molekularnu medicinu i biotehnologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
Errors in ribosome biogenesis can result in quantitative or qualitative defects in protein synthesis and conse- quently lead to improper execution of the genetic program and the development of speci fi c diseases. Evidence has accumulated over the last decade suggesting that perturbation of ribosome biogenesis triggers a p53- activating checkpointsignaling pathway,often referred to as the ribosome biogenesis stress checkpoint pathway. Although it was originally suggested that p53 has a pro minent role in preventing diseases by monitoring the fi delity of ribosome biogenesis, recent work has demonstrated that p53 activation upon impairment of ribosome biogenesis also mediates pathological manifestations in humans . Perturbations of ribosome biogenesis can trigger a p53-dependent checkpoint signaling pathway independent of DNA damage and the tumor suppressor ARF through inhibitory interactions of speci fi c ribosomal components with the p53 negative regulator, Mdm2. Here we review the recent advances made toward understanding of this newly-recognized checkpoint signaling pathway, its role in health and disease, and discuss possible future directions in this exciting research fi eld. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBBA - Biochimica et Biophysica Acta
Brojčani podacivol. 1842, str. 817-830
p-ISSN0006-3002
DOIhttps://doi.org/10.1016/j.bbadis.2013.08.014
URN:NBNurn:nbn:hr:184:017875
Datum objave publikacije2014
ProjektŠifra: 223151
Naziv (engleski): Understanding inflammation-associated tumorigenesis for the rational design of novel anti-cancer therapeutic strategies.
Kratica: INFLA-CARE
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
URL dokumentahttps://doi.org/10.1016/j.bbadis.2013.08.014
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
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Datum i vrijeme pohrane2018-10-14 18:36:28