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Chloroquine urea derivatives: synthesis and antitumor activity in vitro
Acta Pharmaceutica, 68 (2018), 4; 471-483. https://doi.org/10.2478/acph-2018-0039
Pavić, Kristina; Rajić, Zrinka; Mlinarić, Zvonimir; Uzelac, Lidija; Kralj, Marijeta; Zorc, Branka

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Pavić, K., Rajić, Z., Mlinarić, Z., Uzelac, L., Kralj, M. i Zorc, B. (2018). Chloroquine urea derivatives: synthesis and antitumor activity in vitro. Acta Pharmaceutica, 68. (4), 471-483. doi: 10.2478/acph-2018-0039

Pavić, Kristina, et al. "Chloroquine urea derivatives: synthesis and antitumor activity in vitro." Acta Pharmaceutica, vol. 68, br. 4, 2018, str. 471-483. https://doi.org/10.2478/acph-2018-0039

Pavić, Kristina, Zrinka Rajić, Zvonimir Mlinarić, Lidija Uzelac, Marijeta Kralj i Branka Zorc. "Chloroquine urea derivatives: synthesis and antitumor activity in vitro." Acta Pharmaceutica 68, br. 4 (2018): 471-483. https://doi.org/10.2478/acph-2018-0039

Pavić, K., et al. (2018) 'Chloroquine urea derivatives: synthesis and antitumor activity in vitro', Acta Pharmaceutica, 68(4), str. 471-483. doi: 10.2478/acph-2018-0039

Pavić K, Rajić Z, Mlinarić Z, Uzelac L, Kralj M, Zorc B. Chloroquine urea derivatives: synthesis and antitumor activity in vitro. Acta Pharmaceutica [Internet]. 2018. [pristupljeno 18.04.2024.];68(4):471-483. doi: 10.2478/acph-2018-0039

K. Pavić, Z. Rajić, Z. Mlinarić, L. Uzelac, M. Kralj i B. Zorc, "Chloroquine urea derivatives: synthesis and antitumor activity in vitro", Acta Pharmaceutica, vol. 68, br. 4, str. 471-483, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:361119. [Citirano: 18.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:163:361119
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Podaci o radu
Naslov (engleski)Chloroquine urea derivatives: synthesis and antitumor activity in vitro
AutorKristina Pavić
AutorZrinka Rajić
AutorZvonimir Mlinarić
AutorLidija Uzelac
AutorMarijeta Kralj
AutorBranka Zorc
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za farmaceutsku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Farmacija
Sažetak (engleski)
In the current paper, we describe design, synthesis and antiproliferative screening of novel chloroquine derivatives with a quinoline core linked to a hydroxy or halogen amine through a flexible aminobutyl chain and urea spacer. Synthetic pathway leading to chloroquine urea derivatives 4-10 includes two crucial steps: i) synthesis of chloroquine benzotriazolide 3 and ii) formation of the urea derivatives through the reaction of compound 3 with the corresponding amine. Testing of antiproliferative activity against four human cancer cell lines revealed that chloroquine urea derivatives 9 and 10 with aromatic moieties show activity in micromolar concentrations. Therefore, these molecules represent interesting lead compounds that might provide insight into the design of new anticancer agents.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Pharmaceutica
Brojčani podacivol. 68, br. 4, str. 471-483
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2018-0039
URN:NBNurn:nbn:hr:163:361119
Datum objave publikacije2018
URL dokumentahttps://hrcak.srce.hr/203273
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-04-07 15:49:49