prikaz prve stranice dokumenta Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid
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Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid
Croatica Chemica Acta, 81 (2008), 3; 453-459. urn:nbn:hr:163:291574
Nigović, Biljana; Komorsky-Lovrić, Šebojka; Devčić, Dubravka

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Nigović, B., Komorsky Lovrić, Š. i Devčić, D. (2008). Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid. Croatica Chemica Acta, 81. (3), 453-459. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:163:291574

Nigović, Biljana, et al. "Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid." Croatica Chemica Acta, vol. 81, br. 3, 2008, str. 453-459. https://urn.nsk.hr/urn:nbn:hr:163:291574

Nigović, Biljana, Šebojka Komorsky Lovrić i Dubravka Devčić. "Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid." Croatica Chemica Acta 81, br. 3 (2008): 453-459. https://urn.nsk.hr/urn:nbn:hr:163:291574

Nigović, B., Komorsky Lovrić, Š. i Devčić, D. (2008) 'Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid', Croatica Chemica Acta, 81(3), str. 453-459. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:163:291574 (Datum pristupa: 18.04.2024.)

Nigović B, Komorsky Lovrić Š, Devčić D. Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid. Croatica Chemica Acta [Internet]. 2008. [pristupljeno 18.04.2024.];81(3):453-459. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:291574

B. Nigović, Š. Komorsky Lovrić i D. Devčić, "Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid", Croatica Chemica Acta, vol. 81, br. 3, str. 453-459, 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:291574. [Citirano: 18.04.2024.]

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Naslov (engleski)Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid
AutorBiljana Nigović
AutorŠebojka Komorsky-Lovrić
AutorDubravka Devčić
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za analitiku i kontrolu lijekova)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Farmacija
Sažetak (engleski)
Simvastatin is used as an antilipemic agent through inhibition of 3-hydroxy-3-methylglutarylcoenzyme A reductase. The reduction behavior of drug has been studied in different supporting electrolytes within the pH range 3–9. Based on the adsorptive character of simvastatin onto the mercury electrode surface, a new cathodic square-wave stripping voltammetry method for its direct determination at trace levels has been proposed. The voltammetric response could be used to determine drug concentration in the range 1.0 × 10–8 to 7.5 × 10–7 mol L–1, with detection limit of 4.5 × 10–9 mol L–1. Applicability to biological fluid analysis was illustrated. The method was successfully employed, without sample pretreatment, for quantitation of the active ingredient simvastatin in pharmaceuticals. The use of abrasive stripping voltammetry for rapid identification of this drug in pharmaceutical dosage forms using a paraffin-impregnated graphite electrode has been examined.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatica Chemica Acta
Brojčani podacivol. 81, br. 3, str. 453-459
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:163:291574
Datum objave publikacije2008
URL dokumentahttps://hrcak.srce.hr/31133
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-04-21 15:27:49