prikaz prve stranice dokumenta Exploring a new nuclear mRNA surveillance pathway in Saccharomyces cerevisiae
Pristup korisnicima matične ustanove
diplomski rad
Exploring a new nuclear mRNA surveillance pathway in Saccharomyces cerevisiae
2013. urn:nbn:hr:159:085655
Martinić, Ivana
Sveučilište u Zagrebu
Prehrambeno-biotehnološki fakultet
Zavod za kemiju i biokemiju
Laboratorij za biokemiju

Citirajte ovaj rad

Martinić, I. (2013). Exploring a new nuclear mRNA surveillance pathway in Saccharomyces cerevisiae (Diplomski rad). Zagreb: Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:159:085655

Martinić, Ivana. "Exploring a new nuclear mRNA surveillance pathway in Saccharomyces cerevisiae." Diplomski rad, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet, 2013. https://urn.nsk.hr/urn:nbn:hr:159:085655

Martinić, Ivana. "Exploring a new nuclear mRNA surveillance pathway in Saccharomyces cerevisiae." Diplomski rad, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet, 2013. https://urn.nsk.hr/urn:nbn:hr:159:085655

Martinić, I. (2013). 'Exploring a new nuclear mRNA surveillance pathway in Saccharomyces cerevisiae', Diplomski rad, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet, citirano: 12.04.2025., https://urn.nsk.hr/urn:nbn:hr:159:085655

Martinić I. Exploring a new nuclear mRNA surveillance pathway in Saccharomyces cerevisiae [Diplomski rad]. Zagreb: Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet; 2013 [pristupljeno 12.04.2025.] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:159:085655

I. Martinić, "Exploring a new nuclear mRNA surveillance pathway in Saccharomyces cerevisiae", Diplomski rad, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet, Zagreb, 2013. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:159:085655

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Podaci o radu
NaslovExploring a new nuclear mRNA surveillance pathway in Saccharomyces cerevisiae
AutorIvana Martinić
MentorVladimir Mrša (mentor)
Ustanova koja je dodijelila
akademski / stručni stupanj		Sveučilište u Zagrebu
Prehrambeno-biotehnološki fakultet
(Zavod za kemiju i biokemiju)
(Laboratorij za biokemiju)
Zagreb
Datum i država obrane2013-07-01, Hrvatska
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Biotehnologija
Sažetak
The messenger ribonucleoprotein particle (mRNP) biogenesis is a complex and integrated nuclear process in which a numerous different events are coordinated and coupled. Such events include transcription, pre-mRNA processing (5'end capping, splicing, 3'end cleavage, and poly(A) adition), mRNP formation and export, as well as quality controls. The aberrant transcripts resulting from improper mRNP biogenesis are targeted by the quality control mechanism, causing their retention in the nucleus and... Više degradation by the 3'-5' exoribonuclease Rrp6, which is associated to the exosome. Recently, in our laboratory an inovative assay to study the coupling and coordination between biogenesis and quality control of mRNPs in yeast S. cerevisiae, was implemented. It was shown that bacterial Rho factor, RNA dependent helicase/translocase, functions as a powerful molecular motor that can disrupt RNA-protein complexes present on its path which results with production of full length yet aberrant transcripts. In accordance to currently results which show that Rat1p is involved in a new 5' end quality control, we wanted to test the involvement of possible Rat1p cofactors, Rai1 and Dxo1 proteins, in this new surveillance mechanism. In this work we used properties of the Rho factor to produce improperly processed mRNPs, and showed directly by ChIP experiment that Rat1 homolog, Rai1p, is involved in this quality control. Suprisingly we found that two structural homologs , Rai1 and Dxo1, are not redundant. Sakrij dio sažetka
Ključne riječi
Jezikengleski
URN:NBNurn:nbn:hr:159:085655
Studijski programNaziv: Molekularna biotehnologija
Vrsta studija: sveučilišni
Stupanj studija: diplomski
Akademski / stručni naziv: magistar/magistra inženjer/inženjerka molekularne biotehnologije (mag. ing. biotechn.)
Vrsta resursaTekst
Način izrade datotekeIzvorno digitalna
Prava pristupaPristup korisnicima matične ustanove
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-05-05 11:15:32
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