The in vitro release test of the active pharmaceutical ingredient is increasingly applied to the pharmaceutical industry because it is extremely important for the quality assurance of products, particularly solid oral forms, tablets or capsules. This assay helps to determine the optimal amount of ingredients needed to achieve the desired drug release profiles. The active ingredient can be released by diffusion mechanism or erosion and may have a instant, prolonged or controlled effect. This assignment investigates how changes in hydrodynamic conditions affect the release rate of dronedarone hydrochloride from the Multaq tablets. Different hydrodynamic conditions were achieved by varying the impeller rotational speed, whereby the temperature and viscosity of the medium as well as the impeller diameter were kept constant. The change of dronedarone concentration was determined by UV/Vis spectrophotometer by measuring absorbance. Dronedarone hydrochloride dissolution profiles were obtained and described by kinetic model. The results have shown that dissolution kinetics of dronedarone hydrochloride can be described by a Hopfenberg model suitable for the description of release kinetics from tablets, and implies the rate of erosion of the matrix as a kinetic control mechanism. By increasing Reynolds' number, the trend of increasing the release rate of the active substance has been observed.