Polyvinylpriolidone (PVP) is a polymer which has attracted a great deal of attention since its discovery (Reppe, 1939) until today due to its exceptional properties. It has a unique combination of physical and chemical properties such as biocompatibility, non-toxicity, chemical stability, good solubility in water and many other organic solvents, affinity to complex hydrophilic and hydrophobic substances. It is excellent for creating solid, transparent and glossy film, and due to its non-toxicity and good biocompatibility, it is used, among other things, as a binder for tablets in pharmaceutical applications. By exploring its good properties, it has been shown that PVP based biomaterials have certain disadvantages and therefore various fillers are addedd to the PVP matrix to improve it's properties. In this paper, the influence of iron (III) oxide (Fe2O3) and iron (Fe) filler addition, on the properties of PVP polymer, was investigated. PVP/Fe2O3 and PVP/Fe composites were prepared by mixing PVP with different filler content, φ = 0,1; 0,3; 0,5 and 1,0 %, in aqueous solution. By measuring the contact angle, the surface energy free of the components was determined and the adhesion parameters were calculated. Structure of PVP polymer and composites was determined by optical microscopy and thermal properties of the samples were investigated by differential scanning calorimetry (DSC), thermal conductivity measurement and thermogravimetric analysis (TGA). The results showed that both fillers were added at too low concentrations to cause some significant changes in the properties of the PVP polymer matrix. According to the calculated adhesion parameters it was concluded that stronger interactions can be expected in composite system PVP/Fe2O3.