Hypodontia is defined as a congenital absence of one or up to six teeth. Its etiology is comprised of genetics, environmental factors, and different combinations of the two. Occurrences can be parts of various syndromes (Ectodermal dysplasia, Down syndrome, Van Der Woude syndrome), or they can be non-sydromatic. Occurrences are possible both in deciduous and permanent dentition and are one of the most frequent craniofacial anomalies in people. The anomaly is more frequent in permanent teeth, with upper lateral incisors, second lower premolars and third molars being the most frequent. Most forms of hypodontia are symmetrical. A diagnose is set after a clinical examination and a radiographic confirmation of tooth absence. Hypodontia rehabilitation requires a multidisciplinary approach, especially in the treatment of upper lateral incisors, the lack of which poses an aesthetic, functional and psychosocial problem for the patient. Therapy may include orthodontic space opening or closing, and consequential implant-prosthodontic, prosthodontic or restorative treatment. This work will demonstrate a case of hypodontia rehabilitation on upper lateral incisors, the patient being a male in his late twenties. The treatment included orthodontic space opening followed by implant-prosthodontic therapy which greatly increased the patient's quality of life. This work will emphasize the need for an individual approach to therapy with patients suffering from hypodontia, since the right choice of therapy will depend on facial features, incisor location, malocclusion presence, size and color of canines and the length of the upper lip. A successful therapy implies a multidisciplinary approach, and the final result must be the elimination of negative psychological impact of hypodontia on the patient's everyday life.