Platelet Rich Fibrin (PRF) is an autologous biomaterial which represents a second-generation of platelet concentrates. It has favourable biological properties that accelerate the healing of soft tissue and bone; therefore, it is widely used in oral surgery and other specialist areas. It is a successor of the platelet - rich plasma (PRP) bringing multiple benefits. PRF technique was presented in 2001 in France by Choukroun and his colleagues. The main elements within the PRF are platelets, leukocyte cytokines and fibrin networks (matrix) which connects them. Platelets serve to form a platelet plug, i.e. a blood clot at the location of damage, while cytokines initiate a series of biological processes required for tissue regeneration. Fibrin promotes hemostasis, but also forms the matrix required for the migration of fibroblasts and endothelial cells, which are involved in angiogenesis and tissue remodelling. PRF is inexpensive and simple method, and it is possible to combine it with other regenerative techniques. Areas of PRF application are: sinus augmentation after lifting the floor of the maxillary sinus, alveolar preservation after tooth extraction, guided bone regeneration, guided tissue regeneration and healing of the soft tissue in mucogingival surgery. Biggest advantages of working with PRF are the simplicity of preparation of PRF, and its availability to each patient, in addition to minimum degree of trauma.