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The Microbial Diversity and Biofilm Characteristics of d-PTFE Membranes Used for Socket Preservation: A Randomized Controlled Clinical Trial
Journal of Functional Biomaterials, 16 (2025), 2; 40. https://doi.org/10.3390/jfb16020040
Franović, Barbara; Čandrlić, Marija; Blašković, Marko; Renko, Ira; Komar Milas, Katarina; Markova-Car, Elitza Petkova; Mohar Vitezić, Bojana; Gabrić, Dragana; Gobin, Ivana; Vranić, Sabina Mahmutović; Perić Kačarević, Željka; Peloza, Olga Cvijanović

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Franović, B., Čandrlić, M., Blašković, M., Renko, I., Komar Milas, K., Markova Car, E. P. ... Peloza, O. C. (2025). The Microbial Diversity and Biofilm Characteristics of d-PTFE Membranes Used for Socket Preservation: A Randomized Controlled Clinical Trial. Journal of Functional Biomaterials, 16. (2). doi: 10.3390/jfb16020040

Franović, Barbara, et al. "The Microbial Diversity and Biofilm Characteristics of d-PTFE Membranes Used for Socket Preservation: A Randomized Controlled Clinical Trial." Journal of Functional Biomaterials, vol. 16, br. 2, 2025. https://doi.org/10.3390/jfb16020040

Franović, Barbara, Marija Čandrlić, Marko Blašković, Ira Renko, Katarina Komar Milas, Elitza Petkova Markova Car, Bojana Mohar Vitezić, et al. "The Microbial Diversity and Biofilm Characteristics of d-PTFE Membranes Used for Socket Preservation: A Randomized Controlled Clinical Trial." Journal of Functional Biomaterials 16, br. 2 (2025). https://doi.org/10.3390/jfb16020040

Franović, B., et al. (2025) 'The Microbial Diversity and Biofilm Characteristics of d-PTFE Membranes Used for Socket Preservation: A Randomized Controlled Clinical Trial', Journal of Functional Biomaterials, 16(2). doi: 10.3390/jfb16020040

Franović B, Čandrlić M, Blašković M, Renko I, Komar Milas K, Markova Car EP, i sur.. The Microbial Diversity and Biofilm Characteristics of d-PTFE Membranes Used for Socket Preservation: A Randomized Controlled Clinical Trial. Journal of Functional Biomaterials [Internet]. 23.01.2025. [pristupljeno 10.03.2025.];16(2). doi: 10.3390/jfb16020040

B. Franović, et al., "The Microbial Diversity and Biofilm Characteristics of d-PTFE Membranes Used for Socket Preservation: A Randomized Controlled Clinical Trial", Journal of Functional Biomaterials, vol. 16, br. 2, Siječanj 2025. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:414388. [Citirano: 10.03.2025.]

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Podaci o radu
Naslov (engleski)The Microbial Diversity and Biofilm Characteristics of d-PTFE Membranes Used for Socket Preservation: A Randomized Controlled Clinical Trial
AutorBarbara Franović
AutorMarija Čandrlić
AutorMarko Blašković
AutorIra Renko
AutorKatarina Komar Milas
AutorElitza Petkova Markova-Car
AutorBojana Mohar Vitezić
AutorDragana Gabrić
AutorIvana Gobin
AutorSabina Mahmutović Vranić
AutorŽeljka Perić Kačarević
AutorOlga Cvijanović Peloza
Autorova ustanova(Klinički bolnički centar Zagreb)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Fakultet za dentalnu medicinu i zdravstvo Osijek
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Dentalna medicina
Sažetak (engleski)
Background: Understanding microbial colonization on different membranes is critical for guided bone regeneration procedures such as socket preservation, as biofilm formation may affect healing and clinical outcomes. This randomized controlled clinical trial (RCT) investigates, for the first time, the microbiome of two different high-density polytetrafluoroethylene (d-PTFE) membranes that are used in socket preservation on a highly molecular level and in vivo. Methods: This RCT enrolled 39... Više participants, with a total of 48 extraction sites, requiring subsequent implant placement. Sites were assigned to two groups, each receiving socket grafting with a composite bone graft (50% autogenous bone, 50% bovine xenograft) and covered by either a permamem® (group P) or a Cytoplast™ (group C). The membranes were removed after four weeks and analyzed using scanning electron microscopy (SEM) for bacterial adherence, qPCR for bacterial species quantification, and next-generation sequencing (NGS) for microbial diversity and composition assessment. Results: The four-week healing period was uneventful in both groups. The SEM analysis revealed multispecies biofilms on both membranes, with membranes from group C showing a denser extracellular matrix compared with membranes from group P. The qPCR analysis indicated a higher overall bacterial load on group C membranes. The NGS demonstrated significantly higher alpha diversity on group C membranes, while beta diversity indicated comparable microbiota compositions between the groups. Conclusion: This study highlights the distinct microbial profiles of two d-PTFE membranes during the four-week socket preservation period. Therefore, the membrane type and design do, indeed, influence the biofilm composition and microbial diversity. These findings may have implications for healing outcomes and the risk of infection in the dental implant bed and should therefore be further explored. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Functional Biomaterials
Brojčani podacivol. 16, br. 2, 40
e-ISSN2079-4983
DOIhttps://doi.org/10.3390/jfb16020040
URN:NBNurn:nbn:hr:127:414388
Datum objave publikacije2025-01-23
URL dokumentahttps://www.mdpi.com/2079-4983/16/2/40
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-10 09:23:22
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