Growth factors are biological mediators which regulate key processes in the restoration of tissue, including cell proliferation, cell differentiation, extracellular matrix synthesis, chemotaxis, and angiogenesis. Growth factors on the membranes of the main targets tie with specific, large glycoproteins—growth factor receptors—thus activating a chain of molecular processes, for which the end result is the beginning of mitosis. Growth factors responsible for the regenerative effect are released from platelet alpha granules during the re-modulation of supplements, inducing angiogenesis and osteogenesis, and the anti-inflammatory effect of leukocytes is manifested by the reduction of inflammatory symptoms and postoperative complications. Apart from their role in hemostasis and inflammation, platelets as a storage of growth factors and they have an important role in bone tissue regeneration. Growth factors that are released from alpha-granules of platelets are: platelet growth factor (PDGF), epidermal growth factor (EGF), transforming growth factors alpha and beta (TGF-α & β), vascular endothelial growth factor (VEFG), fibroblast growth factor (FGF), and an insulin-like growth factor of 1.2 (IGF-1.2). Nowadays, the most frequently used growth factors in dental medicine use leukocyte and platelet rich fibrin (LPRF), leukocyte and platelet rich plasma (LPRP), platelet rich plasma (PRP) and platelet rich fibrin (PRF) methods for faster bone healing. Indications for the use of these supplements in dental medicine include: alveolar preservation after dental extraction, filling the periapical space after apicoectomy, filling the sinus cavity during the sinus lift, as well as in combination with dental implant placement, in the osteonecrosis treatment, and in stimulating other bone healings. The use of growth factors in bone healing has high regenerative potential for healing and a positive effect on postoperative quality of life.