prikaz prve stranice dokumenta Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans
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Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans
Free Radical Biology and Medicine, 162 (2021); 636-641. https://doi.org/10.1016/j.freeradbiomed.2020.11.024
Konjevod, Marcela; Nedić Erjavec, Gordana; Nikolac Perković, Matea; Sáiz, Jorge; Tudor, Lucija; Uzun, Suzana; Kozumplik, Oliver; Švob Štrac, Dubravka; Žarković, Neven; Pivac, Nela

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Konjevod, M., Nedić Erjavec, G., Nikolac Perković, M., Sáiz, J., Tudor, L., Uzun, S. ... Pivac, N. (2021). Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans. Free Radical Biology and Medicine, 162., 636-641. doi: 10.1016/j.freeradbiomed.2020.11.024

Konjevod, Marcela, et al. "Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans." Free Radical Biology and Medicine, vol. 162, 2021, str. 636-641. https://doi.org/10.1016/j.freeradbiomed.2020.11.024

Konjevod, Marcela, Gordana Nedić Erjavec, Matea Nikolac Perković, Jorge Sáiz, Lucija Tudor, Suzana Uzun, Oliver Kozumplik, Dubravka Švob Štrac, Neven Žarković i Nela Pivac. "Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans." Free Radical Biology and Medicine 162 (2021): 636-641. https://doi.org/10.1016/j.freeradbiomed.2020.11.024

Konjevod, M., et al. (2021) 'Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans', Free Radical Biology and Medicine, 162, str. 636-641. doi: 10.1016/j.freeradbiomed.2020.11.024

Konjevod M, Nedić Erjavec G, Nikolac Perković M, Sáiz J, Tudor L, Uzun S, i sur.. Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans. Free Radical Biology and Medicine [Internet]. 01.2021. [pristupljeno 11.04.2024.];162:636-641. doi: 10.1016/j.freeradbiomed.2020.11.024

M. Konjevod, et al., "Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans", Free Radical Biology and Medicine, vol. 162, str. 636-641, Siječanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:993259. [Citirano: 11.04.2024.]

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Podaci o radu
Naslov (engleski)Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans
AutorMarcela Konjevod
AutorGordana Nedić Erjavec
AutorMatea Nikolac Perković
AutorJorge Sáiz
AutorLucija Tudor
AutorSuzana Uzun
AutorOliver Kozumplik
AutorDubravka Švob Štrac
AutorNeven Žarković
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Posttraumatic stress disorder (PTSD) is a severe, multifactorial and debilitating neuropsychiatric disorder, which can develop in a subset of individuals as a result of the exposure to severe stress or trauma. Such traumatic experiences have a major impact on molecular, biochemical and cellular systems, causing psychological and somatic alterations that affect the whole organism. Although the etiology of PTSD is still unclear, it seems to involve complex interaction between various biological genetic and environmental factors. Metabolomics, as one of the rapidly developing "omics" techniques, might be a useful tool for determining altered metabolic pathways and stress-related metabolites as new potential biomarkers of PTSD. The aim of our study was to identify metabolites whose altered levels allow us to differentiate between patients with PTSD and healthy control individuals. The study included two cohorts. The first, exploratory, group included 50 Croatian veterans with PTSD and 50 healthy control subjects, whereas a validation group consisted of 52 veterans with PTSD and 52 control subjects. The metabolomic analysis of plasma samples was conducted using liquid chromatography coupled with mass spectrometry (LC-MS), as well as gas chromatography coupled with mass spectrometry (GC-MS). The LC-MS analysis determined significantly different levels of two glycerophospholipids, PE(18:1/0:0) and PC(18:1/0:0), between control subjects and PTSD patients in both cohorts. The altered metabolites might play a role in multiple cellular processes, including inflammation, mitochondrial dysfunction, membrane breakdown, oxidative stress and neurotoxicity, which could be associated with PTSD pathogenesis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaFree Radical Biology and Medicine
Brojčani podacivol. 162, str. 636-641
p-ISSN0891-5849
e-ISSN1873-4596
DOIhttps://doi.org/10.1016/j.freeradbiomed.2020.11.024
URN:NBNurn:nbn:hr:105:993259
Datum objave publikacije2021-01
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0891584920316373
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2022-02-01
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2021-05-20 08:05:34